4.7 Article

Genetic Factors of Renin-Angiotensin System Associated with Major Bleeding for Patients Treated with Direct Oral Anticoagulants

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Article Chemistry, Medicinal

Gene Polymorphisms of the Renin-Angiotensin System and Bleeding Complications of Warfarin: Genetic-Based Machine Learning Models

Joo-Hee Kim et al.

Summary: This study revealed that carriers of the H2 haplotype of the ACE gene, the G allele of AGT rs5050, and the A allele of AGTR1 rs2640543 are at increased risk of bleeding complications during warfarin treatment. Machine learning methods can be utilized for bleeding prediction, with patients in the highest quartile group of weighted risk score showing a significantly elevated risk of bleeding.

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