期刊
PHARMACEUTICS
卷 13, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13111898
关键词
Diospyros kaki; UV radiation; photoprotection; reactive oxygen species; antimicrobial activity; skin-care cosmetics
资金
- Mnisterio de Ciencia, Innovacion y Universidades [CTM2017-88978-R]
- Agencia Estatal de Investigacion [DI-16-08465]
Persimmon fruits are a rich source of carotenoids, which have protective effects against UV radiation. An acetone extract rich in carotenoids derived from persimmon byproducts was found to have photoprotective and regenerative effects on UV-irradiated HaCaT cells, showing potential for use in skincare products.
Persimmon (Diospyros kaki Thunb.) fruits are a remarkable source of carotenoids, which have shown protective effects against UV radiation in bacteria, fungi, algae, and plants. The aim of this study was to analyze the photoprotection provided by an acetone extract, rich in carotenoids and obtained from byproducts derived from the persimmon juice industry, against UV-induced cell death in the keratinocyte HaCaT cell line. For this purpose, the cytotoxicity and phototoxicity of carotenoid extract, as well as its intracellular reactive oxygen species (ROS) scavenging and anti-adhesive activities towards HaCaT cells, were evaluated. The in vitro permeation test provided information about the permeability of the carotenoid extract. Persimmon extracts, rich in carotenoids (PEC), were absorbed by HaCaT keratinocyte cells, which reduced the UV-induced intracellular ROS production in treated cells. Thus, PEC exerted a photoprotective and regenerative effect on UV-irradiated HaCaT cells, and this protection was UV dose-dependent. No cytotoxic effect was observed in HaCaT cultures at the concentration tested. PEC treatment also stimulated the adhesion capacity of skin microbiome to HaCaT cells, while exhibiting a significant anti-adhesive activity against all tested pathogens. In conclusion, PEC showed potential for use as a functional ingredient in skin-care products.
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