In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion Tablets (vol 13, 1257, 2021)

Summary: This study utilized a streamlined approach to develop ASD tablets, demonstrating the effectiveness of HPMCAS-H grade polymers in both in vitro and in vivo studies. By accurately predicting in vivo performance using in silico simulations, the study showed promise in reducing time and costs for developing ASD drug products.