期刊
PHARMACEUTICS
卷 13, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13122045
关键词
nanoparticles; polymers; brain delivery; blood-brain barrier; controlled drug delivery; therapeutics; nanomedicine
资金
- EuroNanoMed III research program [EURO-NANOMED2017-178]
- Allowance for Top Consortia for Knowledge and Innovation (TKI), made available by the Dutch Ministry of Economic affairs and Alzheimer Netherlands
Safe and reliable entry into the brain is crucial for successful treatment of central nervous system disorders, but remains challenging. Nano-sized systems as drug carriers show significant improvements in therapy delivery. Careful design of NP properties is essential for successful brain delivery, affecting the ability to overcome multiple barriers.
Safe and reliable entry to the brain is essential for successful diagnosis and treatment of diseases, but it still poses major challenges. As a result, many therapeutic approaches to treating disorders associated with the central nervous system (CNS) still only show limited success. Nano-sized systems are being explored as drug carriers and show great improvements in the delivery of many therapeutics. The systemic delivery of nanoparticles (NPs) or nanocarriers (NCs) to the brain involves reaching the neurovascular unit (NVU), being transported across the blood-brain barrier, (BBB) and accumulating in the brain. Each of these steps can benefit from specifically controlled properties of NPs. Here, we discuss how brain delivery by NPs can benefit from careful design of the NP properties. Properties such as size, charge, shape, and ligand functionalization are commonly addressed in the literature; however, properties such as ligand density, linker length, avidity, protein corona, and stiffness are insufficiently discussed. This is unfortunate since they present great value against multiple barriers encountered by the NPs before reaching the brain, particularly the BBB. We further highlight important examples utilizing targeting ligands and how functionalization parameters, e.g., ligand density and ligand properties, can affect the success of the nano-based delivery system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据