期刊
PHARMACEUTICS
卷 14, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics14010065
关键词
polyelectrolyte microcapsules; triggered release; iron oxide nanoparticles; magnetic actuators; Brownian relaxation mechanism; non-heating low frequency magnetic field
资金
- Ministry of Science and Higher Education of the Russian Federation
- Russian Federation [MK-1109.2021.1.3]
- Russian Science Foundation [21-74-10058, 19-72-00095]
- Ministry of Science and Higher Education [0066-2019-0004]
- Russian Science Foundation [19-72-00095, 21-74-10058] Funding Source: Russian Science Foundation
Nanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development. In this study, the researchers developed microcapsules modified with magnetic iron oxide nanoparticles to trigger the release of fluorescently labeled dextran under a low frequency magnetic field. The findings provide new insights for the design of polymer systems for triggered drug release without dangerous heating and overheating of tissues.
Nanosystems for targeted delivery and remote-controlled release of therapeutic agents has become a top priority in pharmaceutical science and drug development in recent decades. Application of a low frequency magnetic field (LFMF) as an external stimulus opens up opportunities to trigger release of the encapsulated bioactive substances with high locality and penetration ability without heating of biological tissue in vivo. Therefore, the development of novel microencapsulated drug formulations sensitive to LFMF is of paramount importance. Here, we report the result of LFMF-triggered release of the fluorescently labeled dextran from polyelectrolyte microcapsules modified with magnetic iron oxide nanoparticles. Polyelectrolyte microcapsules were obtained by a method of sequential deposition of oppositely charged poly(allylamine hydrochloride) (PAH) and poly(sodium 4-styrenesulfonate) (PSS) on the surface of colloidal vaterite particles. The synthesized single domain maghemite nanoparticles integrated into the polymer multilayers serve as magneto-mechanical actuators. We report the first systematic study of the effect of magnetic field with different frequencies on the permeability of the microcapsules. The in situ measurements of the optical density curves upon the 100 mT LFMF treatment were carried out for a range of frequencies from 30 to 150 Hz. Such fields do not cause any considerable heating of the magnetic nanoparticles but promote their rotating-oscillating mechanical motion that produces mechanical forces and deformations of the adjacent materials. We observed the changes in release of the encapsulated TRITC-dextran molecules from the PAH/PSS microcapsules upon application of the 50 Hz alternating magnetic field. The obtained results open new horizons for the design of polymer systems for triggered drug release without dangerous heating and overheating of tissues.
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