期刊
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
卷 45, 期 6, 页码 1987-1996出版社
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyw115
关键词
Acetaminophen; paracetamol; pregnancy; attention function; neurodevelopment; autism spectrum; symptoms
资金
- Instituto de Salud Carlos III [Red INMA G03/176, CB06/02/0041, CP14/00108, FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647]
- Spanish Ministry of Health [FIS-PI041436, FIS-PI081151, FIS-PI06/0867, FIS-PS09/00090]
- Generalitat de Catalunya-CIRIT [(1999SGR 0024)1]
- Miguel Servet (MS) Fellowship - Spanish Institute of Health Carlos III (Ministry of Economy and Competitiveness) [MS14/00108]
- Comissionat per a Universitats i Recerca del Departament d'Innovacio
- Universitats i Empresa de la Generalitat de Catalunya
- Conselleria de Sanitat Generalitat Valenciana [FISS-PI042018, FISS-PI09/02311]
- Obra Social Cajastur
- Universidad de Oviedo
- Department of Health of the Basque Government [2005111093, 2009111069]
- Provincial Government of Gipuzkoa [DFG06/004, DFG08/001]
- Fundacio Roger Torne
Background: Acetaminophen is extensively used during pregnancy. But there is a lack of population-representative cohort studies evaluating its effects on a range of neuropsychological and behavioural endpoints. We aimed to assess whether prenatal exposure to acetaminophen is adversely associated with neurodevelopmental outcomes at 1 and 5 years of age. Methods: This Spanish birth cohort study included 2644 mother-child pairs recruited during pregnancy. The proportion of liveborn participants evaluated at 1 and 5 years was 88.8% and 79.9%, respectively. Use of acetaminophen was evaluated prospectively in two structured interviews. Ever/never use and frequency of use (never, sporadic, persistent) were measured. Main neurodevelopment outcomes were assessed using Childhood Autism Spectrum Test (CAST), Conner's Kiddie Continuous Performance Test (K-CPT) and ADHD-DSM-IV form list. Regression models were adjusted for social determinants and co-morbidities. Results: Over 40% of mothers reported using acetaminophen. Ever-exposed offspring had higher risks of presenting more hyperactivity/impulsivity symptoms [ incidence rate ratio (IRR) = 1.41, 95% confidence interval (CI) 1.01-1.98), K-CPT commission errors (IRR = 1.10,1.03-1.17), and lower detectability scores (coefficient beta = -0.75, -0.13--0.02). CAST scores were increased in ever-exposed males (beta = 0.63, 0.09-1.18). Increased effect sizes of risks by frequency of use were observed for hyperactivity/impulsivity symptoms (IRR = 2.01, 0.95-4.24) in all children, K-CPT commission errors (IRR = 1.32, 1.05-1.66) and detectability (beta = -0.18, -0.36-0.00) in females, and CAST scores inmales (beta = 1.91, 0.44-3.38). Conclusions: Prenatal acetaminophen exposure was associated with a greater number of autism spectrum symptoms in males and showed adverse effects on attention-related outcomes for both genders. These associations seem to be dependent on the frequency of exposure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据