期刊
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
卷 46, 期 1, 页码 209-218出版社
OXFORD UNIV PRESS
DOI: 10.1093/ije/dyw042
关键词
maternal; microbiome; infant; intima-media thickness; cardiovascular
资金
- Murdoch Childrens Research Institute
- Barwon Health
- National Health and Medical Research Council of Australia [APP607370, APP1009044, APP102997, APP1082037, APP1076667, APP1030701, APP1084017]
- Jack Brockhoff Foundation
- Scobie Trust
- Shane O'Brien Memorial Asthma Foundation
- Our Women's Our Children's Fundraising Committee Barwon Health
- Rotary Club of Geelong
- Shepherd Foundation
- Ilhan Foundation
- Sidney Myer Scholarship
- National Health and Medical Research Council (Australia) Fellowship [APP1064629]
- Honorary Future Leader Fellowship of the National Heart Foundation of Australia [100369]
- Future Leader Fellowship from the National Heart Foundation of Australia [100419]
- Victorian Government's Operational Infrastructure Support Program
- Big W
- RCH 1000
- RCH Foundation
- Deakin University
Background: The maternal and infant microbiome may influence infant cardiovascular risk through immune programming. The maternal vagino-enteric microbiome is often sampled for group B streptococcus (GBS) colonization during pregnancy. Our aim was to investigate the association between maternal GBS colonization, intrapartum antibiotics, antenatal pet exposure and infant aortic intima-media thickness (aIMT), an intermediate vascular phenotype, and whether this association varied by mode of delivery. Methods: The Barwon Infant Study is a population-derived pre-birth cohort. Perinatal data were collected on participants. Women were tested for vagino-enteric group B streptococcus (GBS) colonization during third trimester. Six-week infant aIMT was measured by trans-abdominal ultrasound. Adjustment for confounders included maternal age, pre-pregnancy body mass index (BMI), smoking, socioeconomic status, gestational diabetes, length of gestation, infant sex, birthweight and aortic internal diameter. Results: Data were available on 835 mother-infant pairs. Of these, 574 (69%) women delivered vaginally; of those, 129 (22%) were GBS-colonized; and of these women, 111 (86%) received prophylactic intrapartum antibiotics. An association between maternal GBS colonization and infant aIMT was observed among those delivered vaginally (beta = 19.5 mm, 95% CI 9.5, 29.4; P < 0.0001) but not by Caesarean section (P for interaction = 0.02). A similar pattern was seen for intrapartum antibiotics. There was a negative association between antenatal pet exposure and aIMT observed in those delivered vaginally. Conclusion: Maternal GBS colonization and intrapartum antibiotics were associated with increased infant aIMT in those delivered vaginally, whereas antenatal pet exposure was associated with decreased aIMT. These data suggest that differences in early life microbial experience may contribute to an increased cardiovascular risk.
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