4.6 Review

Landscape of TP53 Alterations in Chronic Lymphocytic Leukemia via Data Mining Mutation Databases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Genomic arrays identify high-risk chronic lymphocytic leukemia with genomic complexity: a multicenter study

Alexander C. Leeksma et al.

Summary: Genomic arrays have been shown to be an accurate tool for risk stratification in CLL, with high genomic complexity being an independent adverse prognosticator. Lowering the size cutoff for CNA did not significantly improve risk assessment. Arrays detected more chromosomal abnormalities and performed at least as well as simultaneous chromosome banding analysis for risk stratification.

HAEMATOLOGICA (2021)

Article Biochemistry & Molecular Biology

Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene

Flora Doffe et al.

Summary: Infrequent and rare genetic variants in the human population outnumber common ones significantly. The TP53 coding region shows far more polymorphism than previously thought and presents high ethnic diversity. Analyses of new missense TP53 variants revealed they are benign and do not display loss of function compared to the normal TP53 gene.

CELL DEATH AND DIFFERENTIATION (2021)

Article Oncology

TP53 Mutations with Low Variant Allele Frequency Predict Short Survival in Chronic Lymphocytic Leukemia

Riccardo Bomben et al.

Summary: This study retrospectively analyzed the clinical impact of TP53 mutations in chronic lymphocytic leukemia, finding that TP53 mutations affect overall survival regardless of variant allele frequency. The results of the study suggest updating the definition of TP53 mutated CLL for clinical purposes.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

The Ongoing Unmet Needs in Chronic Lymphocytic Leukemia TP53 Disruption, Richter, and Beyond

Wei Ding

Summary: The HOBSCOTCH program was found to help adults with epilepsy improve subjective executive functioning, especially in working memory. The treatment group showed significant improvements in inhibition, shifting, initiation, and working memory, while the control group only improved in working memory.

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA (2021)

Review Medicine, General & Internal

Treatment of Chronic Lymphocytic Leukemia

Jan A. Burger

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries

Vincent Carbonnier et al.

SCIENTIFIC REPORTS (2020)

Article Medicine, General & Internal

Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions

K. Fischer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Cell Biology

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Lawrence A. Donehower et al.

CELL REPORTS (2019)

Article Biochemistry & Molecular Biology

COSMIC: the Catalogue Of Somatic Mutations In Cancer

John G. Tate et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

Li Ding et al.

Article Biochemistry & Molecular Biology

Quantitative Missense Variant Effect Prediction Using Large-Scale Mutagenesis Data

Vanessa E. Gray et al.

CELL SYSTEMS (2018)

Article Genetics & Heredity

Mutational processes shape the landscape of TP53 mutations in human cancer

Andrew O. Giacomelli et al.

NATURE GENETICS (2018)

Article Oncology

Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation

Lijian Yu et al.

CLINICAL CANCER RESEARCH (2017)

Review Oncology

Clinical Implications of Novel Genomic Discoveries in Chronic Lymphocytic Leukemia

Gregory Lazarian et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Article Genetics & Heredity

REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants

Nilah M. Ioannidis et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2016)

Review Genetics & Heredity

LSDBs and How They Have Evolved

Raymond Dalgleish

HUMAN MUTATION (2016)

Article Genetics & Heredity

Actionable Genes, Core Databases, and Locus-Specific Databases

Amelie Pinard et al.

HUMAN MUTATION (2016)

Article Genetics & Heredity

TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

Liacine Bouaoun et al.

HUMAN MUTATION (2016)

Article Medicine, General & Internal

Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia

Andrew W. Roberts et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Oncology

The molecular pathogenesis of chronic lymphocytic leukaemia

Giulia Fabbri et al.

NATURE REVIEWS CANCER (2016)

Article Biochemical Research Methods

An integrative approach to predicting the functional effects of non-coding and coding sequence variation

Hashem A. Shihab et al.

BIOINFORMATICS (2015)

Article Biochemical Research Methods

GESPA: classifying nsSNPs to predict disease association

Jay K. Khurana et al.

BMC BIOINFORMATICS (2015)

Review Biochemistry & Molecular Biology

TP53: an oncogene in disguise

T. Soussi et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Genetics & Heredity

A general framework for estimating the relative pathogenicity of human genetic variants

Martin Kircher et al.

NATURE GENETICS (2014)

Editorial Material Genetics & Heredity

The Cancer Genome Atlas Pan-Cancer analysis project

John N. Weinstein et al.

NATURE GENETICS (2013)

Article Medicine, General & Internal

Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia

John C. Byrd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Genetics & Heredity

Improving the Assessment of the Outcome of Nonsynonymous SNVs with a Consensus Deleteriousness Score, Condel

Abel Gonzalez-Perez et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

Review Oncology

Translating p53 into the clinic

Chit Fang Cheok et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Letter Genetics & Heredity

Mutation (variation) databases and registries: a rationale for coordination of efforts

Arleen D. Auerbach et al.

NATURE REVIEWS GENETICS (2011)

Article Biochemistry & Molecular Biology

Predicting the functional impact of protein mutations: application to cancer genomics

Boris Reva et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Mathematical & Computational Biology

International Cancer Genome Consortium Data Portal-a one-stop shop for cancer genomics data

Junjun Zhang et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2011)

Letter Biochemical Research Methods

A method and server for predicting damaging missense mutations

Ivan A. Adzhubei et al.

NATURE METHODS (2010)

Letter Biochemical Research Methods

MutationTaster evaluates disease-causing potential of sequence alterations

Jana Marie Schwarz et al.

NATURE METHODS (2010)

Article Biochemical Research Methods

Identifying a High Fraction of the Human Genome to be under Selective Constraint Using GERP plus

Eugene V. Davydov et al.

PLOS COMPUTATIONAL BIOLOGY (2010)

Article Biochemical Research Methods

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

Prateek Kumar et al.

NATURE PROTOCOLS (2009)

Article Biochemistry & Molecular Biology

The codon 47 polymorphism in p53 is functionally significant

XX Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

S Kato et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Predicting deleterious amino acid substitutions

PC Ng et al.

GENOME RESEARCH (2001)

Article Medicine, General & Internal

Genomic aberrations and survival in chronic lymphocytic leukemia.

H Döhner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)