Aberrant Expression of miR-1301 in Human Cancer

miR-1301 is a newly discovered miRNA, which is abnormally expressed in 14 types of tumors. miR-1301 inhibits 23 target genes, forms a ceRNA network with 2 circRNAs and 8 lncRNAs, and participates in 6 signaling pathways, thereby affecting tumor cell proliferation, invasion, metastasis, apoptosis, angiogenesis, etc. Abnormal expression of miR-1301 is often associated with poor prognosis of cancer patients. In addition, miR-1301 is related to the anti-tumor effect of epirubicin on osteosarcoma and imatinib on chronic myeloid leukemia(CML) and can enhance the cisplatin sensitivity of ovarian cancer. This work systematically summarizes the abnormal expression and prognostic value of miR-1301 in a variety of cancers, depicts the miR-1301-related signaling pathways and ceRNA network, and provides potential clues for future miR-1301 research.

Automated summary

miR-1301 is a newly discovered miRNA that is abnormally expressed in multiple types of tumors and is associated with various aspects of tumor progression. Its abnormal expression is correlated with poor prognosis in cancer patients. Additionally, miR-1301 is involved in the anti-tumor effects of certain drugs and can enhance the sensitivity of certain tumors to specific drugs. This study summarizes the expression and functions of miR-1301 in cancer and provides potential directions for future research.