期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.775238
关键词
EMT; radioresistance; mechanisms; strategies; cancer stem cell; tumor microenvironment
类别
资金
- National Natural Science Foundation of China [81672974]
- Natural Science Foundation of Shandong Province [ZR2021QH356, ZR2021LSW023]
Radiotherapy plays a crucial role in cancer treatment, but its effectiveness is often limited by radioresistance. Epithelial-to-mesenchymal transition (EMT), a biological process that gives cancer cells invasive and metastatic properties, as well as radioresistance, has been found to be closely related. Understanding the relationship between EMT and radioresistance is important for improving the efficiency of radiotherapy.
Radiotherapy exerts a crucial role in curing cancer, however, its treatment efficiency is mostly limited due to the presence of radioresistance. Epithelial-to-mesenchymal transition (EMT) is a biological process that endows the cancer cells with invasive and metastatic properties, as well as radioresistance. Many potential mechanisms of EMT-related radioresistance being reported have broaden our cognition, and hint us the importance of an overall understanding of the relationship between EMT and radioresistance. This review focuses on the recent progresses involved in EMT-related mechanisms in regulating radioresistance, irradiation-mediated EMT program, and the intervention strategies to increase tumor radiosensitivity, in order to improve radiotherapy efficiency and clinical outcomes of cancer patients.
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