期刊
FRONTIERS IN ONCOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2022.841625
关键词
microRNA; chemoresistance; autophagy; cancer therapy; non-coding RNA
类别
资金
- National Natural Science Foundation of China [81803790]
- National Natural Science Foundation of Guangdong [2020A1515011090]
- Project of Administration of Traditional Chinese Medicine of Guangdong Province of China [20200511205949]
This article discusses the importance of chemoresistance in cancer treatment, introduces the dual roles of autophagy and miRNA in chemoresistance, and explores the potential of miRNA as a target to overcome chemoresistance.
Chemoresistance frequently occurs in cancer treatment, which results in chemotherapy failure and is one of the most leading causes of cancer-related death worldwide. Understanding the mechanism of chemoresistance and exploring strategies to overcome chemoresistance have become an urgent need. Autophagy is a highly conserved self-degraded process in cells. The dual roles of autophagy (pro-death or pro-survival) have been implicated in cancers and chemotherapy. MicroRNA (miRNA) is a class of small non-coding molecules that regulate autophagy at the post-transcriptional level in cancer cells. The association between miRNAs and autophagy in cancer chemoresistance has been emphasized. In this review, we focus on the dual roles of miRNA-mediated autophagy in facilitating or combating chemoresistance, aiming to shed lights on the potential role of miRNAs as targets to overcome chemoresistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据