Amide Proton Transfer Weighted and Intravoxel Incoherent Motion Imaging in Evaluation of Prognostic Factors for Rectal Adenocarcinoma

ObjectivesTo analyze the value of amide proton transfer (APT) weighted and intravoxel incoherent motion (IVIM) imaging in evaluation of prognostic factors for rectal adenocarcinoma, compared with diffusion weighted imaging (DWI). Materials and MethodsPreoperative pelvic MRI data of 110 patients with surgical pathologically confirmed diagnosis of rectal adenocarcinoma were retrospectively evaluated. All patients underwent high-resolution T-2-weighted imaging (T2WI), APT, IVIM, and DWI. Parameters including APT signal intensity (APT SI), pure diffusion coefficient (D), pseudo-diffusion coefficient (D*), perfusion fraction (f), and apparent diffusion coefficient (ADC) were measured in different histopathologic types, grades, stages, and structure invasion statuses. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficacy, and the corresponding area under the curves (AUCs) were calculated. ResultsAPT SI, D and ADC values of rectal mucinous adenocarcinoma (MC) were significantly higher than those of rectal common adenocarcinoma (AC) ([3.192 +/- 0.661%] vs. [2.333 +/- 0.471%], [1.153 +/- 0.238x10(-3) mm(2)/s] vs. [0.792 +/- 0.173x10(-3) mm(2)/s], and [1.535 +/- 0.203x10(-3) mm(2)/s] vs. [0.986 +/- 0.124x10(-3) mm(2)/s], respectively; all P<0.001). In AC group, the APT SI and D values showed significant differences between low- and high-grade tumors ([2.226 +/- 0.347%] vs. [2.668 +/- 0.638%], and [0.842 +/- 0.148x10(-3) mm(2)/s] vs. [0.777 +/- 0.178x10(-3) mm(2)/s], respectively, both P<0.05). The D value had significant difference between positive and negative extramural vascular invasion (EMVI) tumors ([0.771 +/- 0.175x10(-3) mm(2)/s] vs. [0.858 +/- 0.151x10(-3) mm(2)/s], P<0.05). No significant difference of APT SI, D, D*, f or ADC was observed in different T stages, N stages, perineural and lymphovascular invasions (all P>0.05). The ROC curves showed that the AUCs of APT SI, D and ADC values for distinguishing MC from AC were 0.921, 0.893 and 0.995, respectively. The AUCs of APT SI and D values in distinguishing low- from high-grade AC were 0.737 and 0.663, respectively. The AUC of the D value for evaluating EMVI involvement was 0.646. ConclusionAPT and IVIM were helpful to assess the prognostic factors related to rectal adenocarcinoma, including histopathological type, tumor grade and the EMVI status.

Automated summary

This study found that amide proton transfer (APT) weighted and intravoxel incoherent motion (IVIM) imaging have significant value in evaluating prognostic factors for rectal adenocarcinoma. They can help determine histopathological type, tumor grade, and extramural vascular invasion status.