4.6 Review

Analysis of Subset Chimerism for MRD-Detection and Pre-Emptive Treatment in AML

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biophysics

Midostaurin after allogeneic stem cell transplant in patients with FLT3-internal tandem duplication-positive acute myeloid leukemia

Richard T. Maziarz et al.

Summary: The study evaluated the efficacy of adding midostaurin to standard-of-care treatment in preventing relapse following alloHSCT in FLT3-ITD AML patients. Results showed an 18-month RFS rate of 89% in the midostaurin maintenance therapy group compared to 76% in the SOC group. The inhibition of FLT3 phosphorylation to <70% of baseline was associated with improved RFS, indicating potential clinical benefit in some patients.

BONE MARROW TRANSPLANTATION (2021)

Article Hematology

2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

Michael Heuser et al.

Summary: The European LeukemiaNet MRD Working Party updated the 2018 MRD recommendations, including technical specifications and integrative assessments. They also proposed the use of MRD as a prognostic and surrogate endpoint for drug testing, as well as the clinical implications of MRD assessment in AML. Recommendations include technical requirements for flow cytometry and molecular MRD analysis, as well as reporting methods for MRD results.
Article Biophysics

An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis

Antonio M. Jimenez Jimenez et al.

Summary: The study established an adapted European LeukemiaNet (aELN) risk classification to predict post-transplant outcomes in adult AML patients, finding that patients in the adverse risk group had the highest risk of relapse and inferior disease-free and overall survival, highlighting the need for novel approaches to mitigate relapse in this high-risk group.

BONE MARROW TRANSPLANTATION (2021)

Review Cell Biology

Sequencing-Based Measurable Residual Disease Testing in Acute Myeloid Leukemia

Jennifer M. Yoest et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Relapse of Acute Myeloid Leukemia after Allogeneic Stem Cell Transplantation: Prevention, Detection, and Treatment

Christina Rautenberg et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, General & Internal

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

R. M. Stone et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Oncology

The Prognostic Significance of Measurable (Minimal) Residual Disease in Acute Myeloid Leukemia

Francesco Buccisano et al.

CURRENT HEMATOLOGIC MALIGNANCY REPORTS (2017)

Article Hematology

Outcome and Prognostic Factors for Patients Who Relapse after Allogeneic Hematopoietic. Stem Cell Transplantation

Gita Thanarajasingam et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2013)

Article Hematology

Leukemia Lineage-Specific Chimerism Analysis and Molecular Monitoring Improve Outcome of Donor Lymphocyte Infusions

Darius Sairafi et al.

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2010)