4.6 Article

Valproic Acid Enhanced Temozolomide-Induced Anticancer Activity in Human Glioma Through the p53-PUMA Apoptosis Pathway

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Mutant IDH1 Enhances Temozolomide Sensitivity via Regulation of the ATM/CHK2 Pathway in Glioma

Lin Lin et al.

Summary: The study found that gliomas with IDH1 mutations are more sensitive to TMZ both in vitro and in vivo compared to wild type, with TMZ significantly inhibiting proliferation and inducing more DNA damage and apoptosis in IDH1 mutant cells. The ATM-associated DNA repair signal was impaired in IDH1 mutant cells, and inhibiting the ATM/CHK2 DNA repair pathway further sensitized IDH1 mutant glioma cells to chemotherapy. IDH1 mutation significantly inhibited tumor growth in vivo, and the combination of TMZ and ATM inhibitor enhanced the antitumor effect in IDH1 mutant gliomas.

CANCER RESEARCH AND TREATMENT (2021)

Article Oncology

Clinical features associated with the efficacy of chemotherapy in patients with glioblastoma (GBM): a surveillance, epidemiology, and end results (SEER) analysis

Jieqiong Wen et al.

Summary: Chemotherapy has been shown to improve overall survival and GBM-specific survival in patients with GBM, particularly among those who are younger, have supratentorial tumors, undergo surgery, or radiotherapy. Age, race, tumor location, tumor size, and treatments are identified as independent prognostic factors for patients with glioblastoma.

BMC CANCER (2021)

Review Oncology

MGMT promoter methylation testing to predict overall survival in people with glioblastoma treated with temozolomide: a comprehensive meta-analysis based on a Cochrane Systematic Review

Sebastian Brandner et al.

Summary: In this study, different techniques for measuring MGMT in glioblastoma patients treated with temozolomide were compared, with Methylation-specific PCR (MSP) and pyrosequencing (PSQ) found to be more prognostic than immunohistochemistry. The study did not provide strong evidence on the optimal use of frozen tissue vs formalin-fixed paraffin-embedded tissues or the best CpG sites or threshold. Therefore, further research is needed to determine the most effective methods for predicting survival in these patients.

NEURO-ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?

Yang He et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cell Biology

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

Lawrence A. Donehower et al.

CELL REPORTS (2019)

Article Clinical Neurology

Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma

Bruna Mascaro-Cordeiro et al.

CHILDS NERVOUS SYSTEM (2018)

Review Clinical Neurology

The survival effect of valproic acid in glioblastoma and its current trend: a systematic review and meta-analysis

Victor M. Lu et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2018)

Article Pharmacology & Pharmacy

Valproic acid attenuates immunosuppressive function of myeloid-derived suppressor cells

Zhiqi Xie et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2018)

Review Oncology

The p53 Pathway in Glioblastoma

Ying Zhang et al.

CANCERS (2018)

Article Clinical Neurology

Recurrent Glioblastomas Exhibit Higher Expression of Biomarkers with Stem-like Properties

B. N. Nandeesh et al.

JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE (2018)

Article Pharmacology & Pharmacy

Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma

Shinichi Watanabe et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2017)

Review Oncology

Belinostat for the treatment of relapsed or refractory peripheral T-cell lymphoma

Peter Campbell et al.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2017)

Review Oncology

Prophylactic anticonvulsants in patients with primary glioblastoma

Arvin R. Wali et al.

JOURNAL OF NEURO-ONCOLOGY (2017)

Review Biotechnology & Applied Microbiology

Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives

Wojciech Szopa et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Article Oncology

Prognostic relevance of epilepsy at presentation in glioblastoma patients

Sharon Berendsen et al.

NEURO-ONCOLOGY (2016)

Article Genetics & Heredity

TP53 Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

Liacine Bouaoun et al.

HUMAN MUTATION (2016)

Review Biochemistry & Molecular Biology

Temozolomide resistance in glioblastoma multiforme

Sang Y. Lee

GENES & DISEASES (2016)

Article Oncology

Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs

France-Helene Paradis et al.

BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY (2015)

Article Medicine, General & Internal

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

Jeanette E. Eckel-Passow et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Multidisciplinary Sciences

The Evidence of Glioblastoma Heterogeneity

Akio Soeda et al.

SCIENTIFIC REPORTS (2015)

Review Hematology

Panobinostat for the treatment of multiple myeloma: the evidence to date

Hanna Bailey et al.

JOURNAL OF BLOOD MEDICINE (2015)

Review Oncology

Unravelling mechanisms of p53-mediated tumour suppression

Kathryn T. Bieging et al.

NATURE REVIEWS CANCER (2014)

Article Biochemistry & Molecular Biology

The Somatic Genomic Landscape of Glioblastoma

Cameron W. Brennan et al.

Review Clinical Neurology

IDH1 and IDH2 Mutations in Gliomas

Adam L. Cohen et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2013)

Article Multidisciplinary Sciences

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

Andrea Sottoriva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Clinical Neurology

Effect of valproic acid on the outcome of glioblastoma multiforme

Hong-Chieh Tsai et al.

BRITISH JOURNAL OF NEUROSURGERY (2012)

Review Chemistry, Medicinal

Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed

Berkley E. Gryder et al.

FUTURE MEDICINAL CHEMISTRY (2012)

Article Biotechnology & Applied Microbiology

Valproic Acid Downregulates the Expression of MGMT and Sensitizes Temozolomide-Resistant Glioma Cells

Chung Heon Ryu et al.

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2012)

Article Genetics & Heredity

Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation

Ching-Hsein Chen et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2011)

Review Clinical Neurology

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

Michael Weller et al.

NATURE REVIEWS NEUROLOGY (2010)

Review Oncology

MGMT promoter methylation in malignant gliomas

Markus J. Riemenschneider et al.

TARGETED ONCOLOGY (2010)

Article Oncology

HDAC Inhibitor, Valproic Acid, Induces p53-Dependent Radiosensitization of Colon Cancer Cells

Xufeng Chen et al.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2009)

Review Oncology

p53 and E2f: partners in life and death

Shirley Polager et al.

NATURE REVIEWS CANCER (2009)

Review Biochemistry & Molecular Biology

PUMA, a potent killer with or without p53

J. Yu et al.

ONCOGENE (2008)

Review Clinical Neurology

The 2007 WHO classification of tumours of the central nervous system

David N. Louis et al.

ACTA NEUROPATHOLOGICA (2007)

Article Biotechnology & Applied Microbiology

Therapeutic efficacy of PUMA for malignant glioma cells regardless of p53 status

H Ito et al.

HUMAN GENE THERAPY (2005)

Article Medicine, General & Internal

MGMT gene silencing and benefit from temozolomide in glioblastoma

ME Hegi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Biochemistry & Molecular Biology

The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

OH Krämer et al.

EMBO JOURNAL (2003)

Article Clinical Neurology

p53, mdm2, EGFR, and msh2 expression in paired initial and recurrent glioblastoma multiforme

AM Stark et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2003)

Article Biochemistry & Molecular Biology

PUMA, a novel proapoptotic gene, is induced by p53

K Nakano et al.

MOLECULAR CELL (2001)