4.6 Article

Targeting miR-185-3p Inhibits Head and Neck Squamous Cell Carcinoma by Modulating RAB25

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FRONTIERS IN ONCOLOGY
卷 11, 期 -, 页码 -

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FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.721416

关键词

head and neck squamous cell carcinoma; exosome; miR-185-3p; RAB25; tumor growth

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资金

  1. National Science Foundation [82071023]
  2. Henan Natural Science Foundation [202300410382]
  3. Youth Foundation of The First affiliated Hospital of ZhengZhou University

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The study reveals that exosomal miR-185-3p promotes tumor growth by mediating RAB25, which can be effectively targeted for HNSCC treatment. Targeting miR-185-3p/RAB25 significantly inhibits tumor growth and enhances drug response to chemotherapy.
Cancer cell-derived exosomes regulate tumor growth and progression. However, the effects of exosomes and its contents on head and neck squamous cell carcinoma (HNSCC) and its underlying mechanisms remain unclear. Here, we found HNSCC displayed a dysregulation of exosomes biogenesis. miR-185-3p was one of the most upregulated exosome-derived miRNAs in HNSCC. Functional assay showed that RAB25 is a direct downstream target of miR-185-3p. miR-185-3p/RAB25 signaling controlled tumor progression and correlated with disease prognosis. Targeting miR-185-3p/RAB25 significantly inhibited tumor growth and promoted drug response to chemotherapy. To conclude, the findings demonstrate exosomal miR-185-3p promotes tumor growth by mediating RAB25 that could be effectively targeted for HNSCC treatment.

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