Establishment of human distal lung organoids for SARS-CoV-2 infection

Review Clinical Neurology

Why do SARS-CoV-2 NSPs rush to the ER?

Maryline Santerre et al.

Summary: The NSPs of the virus play a crucial role in establishing the replication and transcription complex by hijacking the endoplasmic reticulum membrane, potentially leading to central nervous system damage and neurodegeneration. Research on these NSPs will not only reveal their specific role in viral infection but also aid in the discovery of novel targeted drugs.

JOURNAL OF NEUROLOGY (2021)

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Article Biochemistry & Molecular Biology

An organoid-derived bronchioalveolar model for SARS-CoV-2 infection of human alveolar type II-like cells

Mart M. Lamers et al.

Summary: This study describes a human 2D air-liquid interface culture system for studying interactions between SARS-CoV-2 and host cells, showing potential as an experimental model and drug screening tool. The system is characterized by the infection of alveolar cells and induction of interferon response, with interferon lambda 1 treatment reducing viral replication.

EMBO JOURNAL (2021)

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Article Cell Biology

SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery

Apoorva Mulay et al.

Summary: This study established primary human lung epithelial infection models to investigate the initial responses of proximal and distal lung epithelium to SARS-CoV-2 infection. The findings showed that epithelial cells in different areas of the lungs are susceptible to SARS-CoV-2 infection, leading to a cell-autonomous proinflammatory response, with remdesivir proving effective in suppressing viral infection and replication.

CELL REPORTS (2021)

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Article Biochemistry & Molecular Biology

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes

Neal G. Ravindra et al.

Summary: The study provides insights into the replication, cell tropism, and host-viral interactions of SARS-CoV-2 in human bronchial epithelial cells. It highlights ciliated cells as a major initial target of infection, with the virus later expanding its cell tropism to include other epithelial cell types. Infection induces expression of interferons and interferon-stimulated genes, providing a detailed characterization of gene expression and cell state changes associated with SARS-CoV-2 infection in the human airway.

PLOS BIOLOGY (2021)

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Article Multidisciplinary Sciences

Identification of SARS-CoV-2 inhibitors using lung and colonic organoids

Yuling Han et al.

Summary: Researchers have developed lung and colonic organoid models using human pluripotent stem cells, which demonstrate susceptibility to SARS-CoV-2 infection. These models are valuable for studying the infection of the virus and screening drugs, with potential therapeutic implications for COVID-19.

NATURE (2021)

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Article Biochemistry & Molecular Biology