期刊
CELL DISCOVERY
卷 7, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41421-021-00329-3
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类别
资金
- National Key RD Program [2020YFC2002800]
- Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai
- Major Program of Development Fund for Shanghai Zhangjiang National Innovation Demonstration Zone 'Stem Cell Strategic Biobank and Stem Cell Clinical Technology Transformation Platform' [ZJ2018-ZD-004]
- Pudong New Area Clinical Traditional Chinese Medicine of Top Discipline Project [PDZY-2018-0603]
- Key R&D Program of Jiangsu [BE2020026]
Large-scale COVID-19 vaccinations are currently underway, causing consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers. Single-cell mRNA sequencing also revealed changes in gene expression of immune cells, suggesting that vaccination mimics infection. Increased NF-kappa B signaling and reduced type I interferon responses were observed, indicating caution is needed when vaccinating individuals with pre-existing clinical conditions.
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in COVID-19 patients, suggesting that vaccination mimicked an infection. Single-cell mRNA sequencing (scRNA-seq) of peripheral blood mononuclear cells (PBMCs) before and 28 days after the first inoculation also revealed consistent alterations in gene expression of many different immune cell types. Reduction of CD8(+) T cells and increase in classic monocyte contents were exemplary. Moreover, scRNA-seq revealed increased NF-kappa B signaling and reduced type I interferon responses, which were confirmed by biological assays and also had been reported to occur after SARS-CoV-2 infection with aggravating symptoms. Altogether, our study recommends additional caution when vaccinating people with pre-existing clinical conditions, including diabetes, electrolyte imbalances, renal dysfunction, and coagulation disorders.
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