Application Value of Serum Multi-Antibody Combined Detection in Differential Diagnosis and Typing of Lung Cancer

One of the most prevalent malignant tumours is lung cancer. Circulating microRNAs (miRNAs) have shown to have significant promise for lung cancer diagnosis and prognosis, according to a growing body of research. The researchers wanted to explore if serum exosomal miR-1246 has any treatment significance in patients with non-small-cell lung cancer (NON-SCLC). Real-time PCR was used to determine the stage of exosomal miR-1246 serum expression in NON-SCLC patients. The researchers next looked into the link regarding exosomal miR-1246 serum stages and NON-SCLC prognosis. In NON-SCLC patients, exosomal miR-1246 serum appearance was considerably higher. According to a receiver operating characteristic (ROC) research, serum exosomal miR-1246 was effective in discriminating NON-SCLC patients from normal controls and non-malignant respiratory illness patients. Following treatment, the amount of serum exosomal miR-1246 reduced but increased in cases of recurrence. Furthermore, the level of serum exosomal miR-1246 was connected to distant metastases and TNM stages in a significant way. According to a survival analysis, cases with severe levels of exosomal miR-1246 serum had reduced overall or disease-free survival. The level of exosomal miR-1246 serum was found to be an autonomous predictive issue for NON-SCLC in multi-variate analysis. Finally, exosomal miR-1246 serum may be a useful prognosis biomarker for non-small-cell lung cancer.

Automated summary

This study suggests that serum exosomal miR-1246 has significant treatment significance in non-small-cell lung cancer (NSCLC) patients. The level of serum exosomal miR-1246 is considerably higher in NSCLC patients and is significantly associated with distant metastases and TNM stages. After treatment, the level of serum exosomal miR-1246 decreases but increases in cases of recurrence. Severe levels of exosomal miR-1246 serum are associated with lower overall or disease-free survival. Therefore, serum exosomal miR-1246 may serve as a useful prognosis biomarker for NSCLC.