期刊
CELLS
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/cells10112987
关键词
congenital pulmonary airway malformation (CPAM); bronchopulmonary sequestration; bronchogenic cysts; congenital diaphragmatic hernia (CDH); congenital malformations
类别
资金
- Foundation for Science and Technology (FCT) [UIDB/50026/2020, UIDP/50026/2020]
- FCT , Inter-University Doctoral Programme in Ageing and Chronic Disease (PhDOC) [PD/BD/137655/2018]
- Fundação para a Ciência e a Tecnologia [PD/BD/137655/2018] Funding Source: FCT
Lung organogenesis is a highly coordinated process regulated by a network of signaling pathways, which determine the formation of a functional organ. Abnormalities such as bronchial malformations can affect lung function. This review focuses on uncovering the molecular mechanisms underlying normal/abnormal lung growth and development and their impact on postnatal survival.
Lung organogenesis is a highly coordinated process governed by a network of conserved signaling pathways that ultimately control patterning, growth, and differentiation. This rigorously regulated developmental process culminates with the formation of a fully functional organ. Conversely, failure to correctly regulate this intricate series of events results in severe abnormalities that may compromise postnatal survival or affect/disrupt lung function through early life and adulthood. Conditions like congenital pulmonary airway malformation, bronchopulmonary sequestration, bronchogenic cysts, and congenital diaphragmatic hernia display unique forms of lung abnormalities. The etiology of these disorders is not yet completely understood; however, specific developmental pathways have already been reported as deregulated. In this sense, this review focuses on the molecular mechanisms that contribute to normal/abnormal lung growth and development and their impact on postnatal survival.
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