期刊
CELLS
卷 10, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/cells10113186
关键词
genomics; glucocorticoid receptor; IgA nephropathy; membranous nephropathy; single nucleotide polymorphism
类别
资金
- Medical University of Warsaw [1W21/M/MG1/N/20]
- Compensa TU S.A. Vienna Insurance Group [1W21/DAR55/20]
- NIH/NIDDK [2U01DK100876]
Glomerular diseases such as IgA nephropathy and membranous nephropathy are influenced by NR3C1 gene polymorphisms, which can affect treatment susceptibility and clinical outcomes. Specific associations were found between certain SNPs and these diseases, as well as response to steroid therapy.
Glomerular diseases (GNs) are responsible for approximately 20% of chronic kidney diseases. Glucocorticoid receptor gene (NR3C1) single nucleotide polymorphisms (SNPs) are implicated in differences in predisposition to autoimmunity and steroid sensitivity. The aim of this study was to evaluate the frequency of the NR3C1 SNPs-rs6198, rs41423247 and rs17209237-in 72 IgA nephropathy (IgAN) and 38 membranous nephropathy (MN) patients compared to 175 healthy controls and to correlate the effectiveness of treatment in IgAN and MN groups defined as a reduction of proteinuria < 1 g/24 h after 12 months of treatment. Real-time polymerase chain reactions and SNP array-based typing were used. We found significant rs41423247 association with MN (p = 0.026); a significant association of rs17209237 with eGFR reduction after follow-up period in all patients with GNs (p = 0.021) and with the degree of proteinuria after 1 year of therapy in all patients with a glomerulopathy (p = 0.013) and IgAN (p = 0.021); and in the same groups treated with steroids (p = 0.021; p = 0.012). We also observed the association between rs41423247 and IgAN histopathologic findings (p = 0.012). In conclusion, our results indicate that NR3C1 polymorphisms may influence treatment susceptibility and clinical outcome in IgAN and MN.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据