4.6 Article

Involvement of CRMP2 in Regulation of Mitochondrial Morphology and Motility in Huntington's Disease

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Summary: The inhibition of GSK-3 reduces the toxicity of mHtt and improves HD symptoms by reducing mHtt aggregates in the striatum, increasing levels of autophagic and lysosomal markers. The treatment with L807mts also lowers hyperglycemia and enhances motor-coordination functions in R6/2 mouse model of HD. Additionally, L807mts restores the expression levels of critical neuroprotective factors in the HD striatum, providing neurotrophic support and improving HD symptoms.

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