Emerging Role of Extracellular Vesicles and Cellular Communication in Metastasis

Communication between cancer cells and the surrounding stromal cells of the tumor microenvironment (TME) plays a key role in promoting metastasis, which is the major cause of cancer death. Small membrane-bound particles called extracellular vesicles (EVs) are released from both cancer and stromal cells and have a key role in mediating this communication through transport of cargo such as various RNA species (mRNA, miRNA, lncRNA), proteins, and lipids. Tumor-secreted EVs have been observed to induce a pro-tumorigenic phenotype in non-malignant cells of the stroma, including fibroblasts, endothelial cells, and local immune cells. These cancer-associated cells then drive metastasis by mechanisms such as increasing the invasiveness of cancer cells, facilitating angiogenesis, and promoting the formation of the pre-metastatic niche. This review will cover the role of EV-mediated signaling in the TME during metastasis and highlight the therapeutic potential of targeting these pathways to develop biomarkers and novel treatment strategies.

Automated summary

Communication between cancer cells and stromal cells through extracellular vesicles plays a key role in promoting metastasis. Tumor-secreted EVs induce a pro-tumorigenic phenotype in non-malignant cells of the stroma, driving metastasis through various mechanisms. Targeting these EV-mediated signaling pathways may have therapeutic potential for developing biomarkers and novel treatment strategies.