期刊
CELLS
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cells11030371
关键词
calcium; Orai1; CRAC channel; N-terminus; Loop2
类别
资金
- Austrian Science Fund (FWF) [P33283, P34884]
- Austrian Science Fund (FWF) [P33283, P34884] Funding Source: Austrian Science Fund (FWF)
Orai1, a Ca2+-selective pore in the plasma membrane, is crucial for maintaining Ca2+ homeostasis within a cell. In addition to its C-terminus, the second loop and N-terminus of Orai1 play a multifaceted role in the functioning of CRAC channels.
Orai1, the Ca2+-selective pore in the plasma membrane, is one of the key components of the Ca(2+)release-activated Ca2+ (CRAC) channel complex. Activated by the Ca2+ sensor in the endoplasmic reticulum (ER) membrane, stromal interaction molecule 1 (STIM1), via direct interaction when ER luminal Ca2+ levels recede, Orai1 helps to maintain Ca2+ homeostasis within a cell. It has already been proven that the C-terminus of Orai1 is indispensable for channel activation. However, there is strong evidence that for CRAC channels to function properly and maintain all typical hallmarks, such as selectivity and reversal potential, additional parts of Orai1 are needed. In this review, we focus on these sites apart from the C-terminus; namely, the second loop and N-terminus of Orai1 and on their multifaceted role in the functioning of CRAC channels.
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