Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer's Disease

The deposition of amyloid-beta (A beta) in the brain is a risk factor for Alzheimer's disease (AD). Therefore, new strategies for the stimulation of A beta clearance from the brain can be useful in preventing AD. Transcranial photostimulation (PS) is considered a promising method for AD therapy. In our previous studies, we clearly demonstrated the PS-mediated stimulation of lymphatic clearing functions, including A beta removal from the brain. There is increasing evidence that sleep plays an important role in A beta clearance. Here, we tested our hypothesis that PS at night can stimulate A beta clearance from the brain more effectively than PS during the day. Our results on healthy mice show that A beta clearance from the brain occurs faster at night than during wakefulness. The PS course at night improves memory and reduces A beta accumulation in the brain of AD mice more effectively than the PS course during the day. Our results suggest that night PS is a more promising candidate as an effective method in preventing AD than daytime PS. These data are an important informative platform for the development of new noninvasive and nonpharmacological technologies for AD therapy as well as for preventing A beta accumulation in the brain of people with disorder of A beta metabolism, sleep deficit, elderly age, and jet lag.

Automated summary

Research suggests that transcranial photostimulation at night can more effectively promote A beta clearance from the brain, aiding in the prevention of Alzheimer's disease, particularly in individuals with A beta metabolism disorders, sleep deficits, elderly age, and jet lag.