期刊
CELLS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/cells10102535
关键词
endoplasmic reticulum; Golgi; viruses; plasma membrane; intracellular trafficking; vesicles; membrane rearrangements
类别
资金
- UAEU [31R0135, 12M091]
- Al Jalila Foundation [21M132]
- ZonMW TOP [ALWOP.310, ENW KLEIN-1 (OCENW.KLEIN.118)]
- Marie Sklodowska-Curie Cofund grant under the European Union [91217002]
- [713660]
Eukaryotic cells contain dynamic membrane-bound organelles like the endoplasmic reticulum, Golgi apparatus, and plasma membrane, interconnected by vesicular traffic. Viruses exploit these organelles in the secretory pathway for their own replication, assembly, and infection, hijacking the host cell machinery.
Eukaryotic cells contain dynamic membrane-bound organelles that are constantly remodeled in response to physiological and environmental cues. Key organelles are the endoplasmic reticulum, the Golgi apparatus and the plasma membrane, which are interconnected by vesicular traffic through the secretory transport route. Numerous viruses, especially enveloped viruses, use and modify compartments of the secretory pathway to promote their replication, assembly and cell egression by hijacking the host cell machinery. In some cases, the subversion mechanism has been uncovered. In this review, we summarize our current understanding of how the secretory pathway is subverted and exploited by viruses belonging to Picornaviridae, Coronaviridae, Flaviviridae, Poxviridae, Parvoviridae and Herpesviridae families.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据