Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment

Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.

Automated summary

This review discusses how genetic alterations and metabolism pathways in Glioblastoma (GBM) influence tumor immune cells and the tumor microenvironment, and provides an overview of the strategies being tested.