4.6 Review

The Many Potential Fates of Non-Canonical Protein Substrates Subject to NEDDylation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Diverse and pivotal roles of neddylation in metabolism and immunity

Tao Zou et al.

Summary: Neddylation is a protein post-translational modification that involves conjugating a ubiquitin-like protein to substrate proteins via a cascade of E1, E2, and E3 enzymes. Apart from the well-characterized cullins, noncullin neddylation targets have been discovered, suggesting diverse biological functions of neddylation. Neddylation is implicated in various cellular processes such as cell cycle progression, metabolism, immunity, and tumorigenesis.

FEBS JOURNAL (2021)

Article Cell Biology

Neddylation of PTEN regulates its nuclear import and promotes tumor development

Ping Xie et al.

Summary: In this study, it was discovered that under high glucose conditions, PTEN is conjugated by Nedd8, leading to its nuclear import and promoting cell proliferation, metabolism, and fatty acid synthesis. Neddylated PTEN was found to be associated with tumor progression and poor prognosis in breast cancer tissues.

CELL RESEARCH (2021)

Article Cell Biology

Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation

Sofia Lobato-Gil et al.

Summary: The study highlights the significance of NEDD8 in controlling biological processes through specific enzymes. By identifying unique NEDDylation sites and distinct proteomes, the research underscores the diverse role of canonical and atypical NEDDylation. Furthermore, the formation of poly-NEDD8 and other chains suggests potential molecular signals in response to proteotoxic stress.

CELL REPORTS (2021)

Article Multidisciplinary Sciences

Stress-induced NEDDylation promotes cytosolic protein aggregation through HDAC6 in a p62-dependent manner

Soyeon Kim et al.

Summary: The study reveals the involvement of NEDD8, HDAC6, and p62 in managing proteotoxic stress by forming cytosolic aggresome-like bodies coupled to the aggresome-autophagy flux.

ISCIENCE (2021)

Article Microbiology

RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response

Chenhui Li et al.

Summary: The neddylation modification is essential for the appropriate activation of the cGAS-STING signaling pathway, affecting the induction of type I interferon and proinflammatory cytokines. The Ube2m-Rnf111 neddylation axis plays a vital role in promoting the activity of the cGAS-STING pathway and neddylation modification is highlighted as important in antiviral defense.

PLOS PATHOGENS (2021)

Article Cell Biology

Direct Conjugation of NEDD8 to the N-Terminus of a Model Protein Can Induce Degradation

Kartikeya Vijayasimha et al.

Summary: The study demonstrates that fusion of NEDD8 to a protein of interest leads to rapid degradation, depending on functional ubiquitin-conjugation system. However, the inhibitor of the E1 activating enzyme for NEDD8 failed to prevent degradation of other destabilized substrates.
Review Cell Biology

Advances in Cancer Treatment by Targeting the Neddylation Pathway

Wenbin Gai et al.

Summary: NEDD8 is a key protein involved in the progression of tumors, with its inhibitor MLN4924 showing promise in treating cancer. Inhibiting the neddylation pathway can effectively halt the development of tumors.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly

Kheewoong Baek et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

Annette M. Vogl et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Article Multidisciplinary Sciences

Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid β-oxidation

Xueying Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Oncology

UBC12-mediatedSREBP-1 neddylation worsens metastatic tumor prognosis

Mi Jeong Heo et al.

INTERNATIONAL JOURNAL OF CANCER (2020)

Letter Biotechnology & Applied Microbiology

Visualizing and interpreting cancer genomics data via the Xena platform

Mary J. Goldman et al.

NATURE BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

The COP9 Signalosome: A Multi-DUB Complex

Wolfgang Dubiel et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

Neddylation promotes protein translocation between the cytoplasm and nucleus

Shaohua Li et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Targeting SCF E3 Ligases for Cancer Therapies

Jing Liu et al.

CULLIN-RING LIGASES AND PROTEIN NEDDYLATION: BIOLOGY AND THERAPEUTICS (2020)

Article Biochemistry & Molecular Biology

The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer

Xijuan Liu et al.

CULLIN-RING LIGASES AND PROTEIN NEDDYLATION: BIOLOGY AND THERAPEUTICS (2020)

Article Biochemistry & Molecular Biology

Viral Manipulations of the Cullin-RING Ubiquitin Ligases

Ying Liu et al.

CULLIN-RING LIGASES AND PROTEIN NEDDYLATION: BIOLOGY AND THERAPEUTICS (2020)

Article Biochemistry & Molecular Biology

Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death

Matthew J. Keuss et al.

EMBO JOURNAL (2019)

Article Medicine, Research & Experimental

Degradation of splicing factor SRSF3 contributes to progressive liver disease

Deepak Kumar et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Microbiology

ISG15 in antiviral immunity and beyond

Yi-Chieh Perng et al.

NATURE REVIEWS MICROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

The E3 ligase C-CBL inhibits cancer cell migration by neddylating the proto-oncogene c-Src

Gun-Woo Lee et al.

ONCOGENE (2018)

Article Multidisciplinary Sciences

NEDDylation promotes nuclear protein aggregation and protects the Ubiquitin Proteasome System upon proteotoxic stress

Chantal M. Maghames et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Functions and substrates of NEDDylation during cell cycle in the silkworm, Bombyx mori

Zhiqing Li et al.

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY (2017)

Article Multidisciplinary Sciences

NEDDylation of PB2 Reduces Its Stability and Blocks the Replication of Influenza A Virus

Tinghong Zhang et al.

SCIENTIFIC REPORTS (2017)

Article Biochemistry & Molecular Biology

Nedd8 targets ubiquitin ligase Smurf2 for neddylation and promote its degradation

Jingyi Shu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

PPARγ neddylation essential for adipogenesis is a potential target for treating obesity

H-S Park et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Multidisciplinary Sciences

NEDDylation promotes stress granule assembly

Aravinth Kumar Jayabalan et al.

NATURE COMMUNICATIONS (2016)

Article Cardiac & Cardiovascular Systems

NEDDylation promotes endothelial dysfunction: A role for HDAC2

Deepesh Pandey et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Review Cell Biology

Protein neddylation: beyond cullin-RING ligases

Radoslav I. Enchev et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Nedd8 Regulates Inflammasome-Dependent Caspase-1 Activation

Jesus A. Segovia et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Cand1 Promotes Assembly of New SCF Complexes through Dynamic Exchange of F Box Proteins

Nathan W. Pierce et al.

Article Biochemistry & Molecular Biology

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination

Teng Ma et al.

MOLECULAR CELL (2013)

Review Biochemistry & Molecular Biology

The Ubiquitin Code

David Komander et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Article Biochemistry & Molecular Biology

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

Roland Hjerpe et al.

BIOCHEMICAL JOURNAL (2012)

Article Biochemistry & Molecular Biology

NEDDylation regulates E2F-1-dependent transcription

Sarah J. Loftus et al.

EMBO REPORTS (2012)

Article Biochemistry & Molecular Biology

Regulation of parkin and PINK1 by neddylation

Yeun Su Choo et al.

HUMAN MOLECULAR GENETICS (2012)

Article Neurosciences

Neddylation positively regulates the ubiquitin E3 ligase activity of parkin

Ji Won Um et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2012)

Article Multidisciplinary Sciences

FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis

Neha Rani et al.

NATURE COMMUNICATIONS (2012)

Article Biochemistry & Molecular Biology

Hypoxia-inducible Factor α Subunit Stabilization by NEDD8 Conjugation Is Reactive Oxygen Species-dependent

Ji-Hye Ryu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Perturbation of 60 S Ribosomal Biogenesis Results in Ribosomal Protein L5-and L11-dependent p53 Activation

Xiao-Xin Sun et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Chemotherapy induces NEDP1-mediated destabilization of MDM2

I. R. Watson et al.

ONCOGENE (2010)

Article Biochemistry & Molecular Biology

Regulation of nucleolar signalling to p53 through NEDDylation of L11

Anders Sundqvist et al.

EMBO REPORTS (2009)

Article Biochemistry & Molecular Biology

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L

Gunter Schmidtke et al.

FEBS LETTERS (2009)

Article Multidisciplinary Sciences

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

Ribosomal proteins are targets for the NEDD8 pathway

Dimitris P. Xirodimas et al.

EMBO REPORTS (2008)

Article Biochemistry & Molecular Biology

NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL

Ryan C. Russell et al.

EMBO REPORTS (2008)

Review Biochemistry & Molecular Biology

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy

Jiefei Geng et al.

EMBO REPORTS (2008)

Article Cell Biology

DEN1 deneddylates non-cullin proteins in vivo

Yaru Chan et al.

JOURNAL OF CELL SCIENCE (2008)

Article Biochemical Research Methods

A targeted proteomic analysis of the ubiquitin-like modifier Nedd8 and associated proteins

Jeffrey Jones et al.

JOURNAL OF PROTEOME RESEARCH (2008)

Article Biochemistry & Molecular Biology

Multimodal Activation of the Ubiquitin Ligase SCF by Nedd8 Conjugation

Anjanabha Saha et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers

Tianwei Li et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2006)

Article Biochemistry & Molecular Biology

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases

Shlomo Oved et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10

Gunter Schmidtke et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Interaction of NUB1 with the proteasome subunit S5a

K Tanji et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Article Cell Biology

Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation

JT Wu et al.

NATURE CELL BIOLOGY (2005)

Article Biochemistry & Molecular Biology

NEDD8 ultimate Buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation

MS Hipp et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Biochemistry & Molecular Biology

PVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

NH Stickle et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

DP Xirodimas et al.

Article Biochemistry & Molecular Biology

Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L

T Tanaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins

HM Mendoza et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1.

T Kamitani et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Biochemistry & Molecular Biology

NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression

K Kito et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)