Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response

Studies described so far suggest that human beta-defensin 2 is an important protein of innate immune response which provides protection for the human organism against invading pathogens of bacterial, viral, fungal, as well as parasitical origin. Its pivotal role in enhancing immunity was proved in infants. It may also be considered a marker of inflammation. Its therapeutic administration has been suggested for maintenance of the balance of systemic homeostasis based on the appropriate composition of the microbiota. It has been suggested that it may be an important therapeutic tool for modulating the response of the immune system in many inflammatory diseases, offering new treatment modalities. For this reason, its properties and role in the human body discussed in this review should be studied in more detail.

Automated summary

Human beta-defensin 2 plays a crucial role in innate immune response, providing protection against various pathogens and potentially serving as a marker of inflammation. Therapeutic administration of this protein has been suggested to maintain systemic homeostasis and modulate immune response in inflammatory diseases, offering new treatment possibilities. Further research is needed to fully explore its properties and role in the human body.