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Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions:: a novel disorder of mtDNA maintenance
Gavin Hudson et al.
BRAIN (2008)
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sites
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JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
Yun-Gui Yang et al.
CELL (2007)
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
Tim J. Schulz et al.
CELL METABOLISM (2007)
The common biology of cancer and ageing
Toren Finkel et al.
NATURE (2007)
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Akinori Takaoka et al.
NATURE (2007)
CRISPR provides acquired resistance against viruses in prokaryotes
Rodolphe Barrangou et al.
SCIENCE (2007)
Free radicals and antioxidants in normal physiological functions and human disease
Marian Valko et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates
Andreas Pichlmair et al.
SCIENCE (2006)
Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia
Sudit S. Mukhopadhyay et al.
JOURNAL OF CELL BIOLOGY (2006)
p16INK4a induces an age-dependent decline in islet regenerative potential
Janakiraman Krishnamurthy et al.
NATURE (2006)
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Anna V. Molofsky et al.
NATURE (2006)
Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection
Yanick J. Crow et al.
NATURE GENETICS (2006)
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion
Christian Frezza et al.
CELL (2006)
Increased cell-to-cell variation in gene expression in ageing mouse heart
Rumana Bahar et al.
NATURE (2006)
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
R Mostoslavsky et al.
CELL (2006)
Understanding the odd science of aging
TBL Kirkwood
CELL (2005)
Mitochondrial permeability transition triggers the release of mtDNA fragments
M Patrushev et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2004)
Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses
LV Collins et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2004)
Ageing muscle:: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function
G Fayet et al.
NEUROMUSCULAR DISORDERS (2002)
Frailty in older adults: Evidence for a phenotype
LP Fried et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2001)
Gene-expression profile of the ageing brain in mice
CK Lee et al.
NATURE GENETICS (2000)