4.6 Review

Human rDNA and Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

The small-molecule BMH-21 directly inhibits transcription elongation and DNA occupancy of RNA polymerase I in vivo and in vitro

Ruth Q. Jacobs et al.

Summary: This study elucidates the mechanism of Pol I inhibition by BMH-21 and represents a critical step forward in the development of this compound and its derivatives for clinical use.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

Regulatory roles of nucleolus organizer region-derived long non-coding RNAs

Qinyu Hao et al.

Summary: The nucleolus serves as the largest sub-nuclear domain for ribosome biogenesis, playing a crucial role in proper protein synthesis and cellular stress responses. Recent discoveries have identified long non-coding RNAs (lncRNAs) in the regulatory network of nucleolar functions, many of which are derived from ribosomal DNA repeats or genomic regions near nucleolus organizer regions (NORs). This highlights the potential of NORs in harboring novel genes involved in nucleolar function regulation.

MAMMALIAN GENOME (2022)

Review Cell Biology

Variability of Human rDNA

Evgeny Smirnov et al.

Summary: The review discusses the causes and types of human rDNA instability, the methods of detection, its distribution within the locus, and its biological significance. Literature data suggests that the variability of rDNA is not only a potential cause of pathology, but also an important but poorly understood aspect of normal cell physiology.
Review Biochemistry & Molecular Biology

Methylation of 45S Ribosomal DNA (rDNA) Is Associated with Cancer and Aging in Humans

Fengqing Shao et al.

Summary: The study found that rDNA methylation in most cancer cases exhibited a consistent pattern, with hypermethylation in the coding region and hypomethylation in the promoter region, likely facilitating cancer cell proliferation and metastasis. In contrast, both the coding and promoter regions of rDNA showed increasing methylation during aging, suggesting a decline in rDNA activity. The discovery of rDNA methylation also hints at its potential application as an epigenetic biomarker in the diagnosis of cancer and aging.

INTERNATIONAL JOURNAL OF GENOMICS (2021)

Article Multidisciplinary Sciences

The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma

Min Pan et al.

Summary: The study found that the small molecule CX-5461 has selective cytotoxicity in high-risk neuroblastoma and synergizes with topoisomerase I inhibitors to improve survival. However, it was discovered that the primary target of CX-5461 in this disease is topoisomerase II beta, not RNA-POL I, raising unexpected safety concerns.

NATURE COMMUNICATIONS (2021)

Review Genetics & Heredity

Ribosomal RNA Transcription Regulation in Breast Cancer

Cecelia M. Harold et al.

Summary: Ribosome biogenesis is dysregulated in cancer cells, making it a potential target for therapy. Novel drugs targeting rDNA transcription machinery offer a promising avenue for breast cancer treatment.
Article Oncology

Chromosomal Translocations in NK-Cell Lymphomas Originate from Inter-Chromosomal Contacts of Active rDNA Clusters Possessing Hot Spots of DSBs

Nickolai A. Tchurikov et al.

Summary: The research indicates that DSB hot spots in rDNA units are closely related to transcription patterns and cancer. The hot spots, named Pleiades, in human rDNA units may lead to translocations resulting in dysregulation of genes controlling development.

CANCERS (2021)

Article Biochemistry & Molecular Biology

Human rDNA copy number is unstable in metastatic breast cancers

Virginia Valori et al.

EPIGENETICS (2020)

Review Biochemistry & Molecular Biology

MicroRNAs and long non-coding RNAs as novel regulators of ribosome biogenesis

Mason A. McCool et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2020)

Article Multidisciplinary Sciences

Nucleolar RNA polymerase II drives ribosome biogenesis

Karan J. Abraham et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Ribosomal DNA harbors an evolutionarily conserved clock of biological aging

Meng Wang et al.

GENOME RESEARCH (2019)

Article Medicine, Research & Experimental

LncRNA PAPAS may promote triple-negative breast cancer by downregulating miR-34a

Yan Kong et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2019)

Article Genetics & Heredity

Reduced ribosomal RNA expression and unchanged ribosomal DNA promoter methylation in oral squamous cell carcinoma

Shanshan Ha et al.

MOLECULAR GENETICS & GENOMIC MEDICINE (2019)

Article Biochemistry & Molecular Biology

Genome-wide analysis of polymerase III-transcribed Alu elements suggests cell-type-specific enhancer function

Xiao-Ou Zhang et al.

GENOME RESEARCH (2019)

Review Biochemistry & Molecular Biology

Keeping ribosomal DNA intact: a repeating challenge

Daniel O. Warmerdam et al.

CHROMOSOME RESEARCH (2019)

Review Biochemistry & Molecular Biology

Small Non-Coding RNAs Derived from Eukaryotic Ribosomal RNA

Marine Lambert et al.

NON-CODING RNA (2019)

Article Biochemistry & Molecular Biology

The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability

Silvana Paredes et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers

Maheshi Udugama et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Cell Biology

The nucleolus, an ally, and an enemy of cancer cells

Dariusz Stepinski

HISTOCHEMISTRY AND CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Small nucleoli are a cellular hallmark of longevity

Varnesh Tiku et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Pre-45s rRNA promotes colon cancer and is associated with poor survival of CRC patients

H. Tsoi et al.

ONCOGENE (2017)

Review Biochemistry & Molecular Biology

A new layer of rRNA regulation by small interference RNAs and the nuclear RNAi pathway

Xufei Zhou et al.

RNA BIOLOGY (2017)

Article Multidisciplinary Sciences

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

Hong Xu et al.

NATURE COMMUNICATIONS (2017)

Article Genetics & Heredity

Ribosomal DNA copy number loss and sequence variation in cancer

Baoshan Xu et al.

PLOS GENETICS (2017)

Article Genetics & Heredity

DNA replication stress restricts ribosomal DNA copy number

Devika Salim et al.

PLOS GENETICS (2017)

Article Multidisciplinary Sciences

Efficient Generation of diRNAs Requires Components in the Posttranscriptional Gene Silencing Pathway

Daisuke Miki et al.

SCIENTIFIC REPORTS (2017)

Article Cell Biology

Nucleolar reorganization in response to rDNA damage

Marjolein van Sluis et al.

CURRENT OPINION IN CELL BIOLOGY (2017)

Review Cell Biology

Nucleolar DNA: the host and the guests

E. Smirnov et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

Caterina Catalanotto et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Oncology

Role of ribosomal protein mutations in tumor development (Review)

Kaveh M. Goudarzi et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2016)

Article Multidisciplinary Sciences

Dynamics of epigenetic regulation at the single-cell level

Lacramioara Bintu et al.

SCIENCE (2016)

Article Biotechnology & Applied Microbiology

Human Ribosomal RNA-Derived Resident MicroRNAs as the Transmitter of Information upon the Cytoplasmic Cancer Stress

Masaru Yoshikawa et al.

BIOMED RESEARCH INTERNATIONAL (2016)

Article Medical Laboratory Technology

Tumor MicroRNA Expression Profiling Identifies Circulating MicroRNAs for Early Breast Cancer Detection

Nerea Matamala et al.

CLINICAL CHEMISTRY (2015)

Review Biochemistry & Molecular Biology

Alu element-containing RNAs maintain nucleolar structure and function

Maiwen Caudron-Herger et al.

EMBO JOURNAL (2015)

Article Genetics & Heredity

Non-canonical ribosomal DNA segments in the human genome, and nucleoli functioning

Natalia S. Kupriyanova et al.

Article Biochemistry & Molecular Biology

miR-663 attenuates tumor growth and invasiveness by targeting eEF1A2 in pancreatic cancer

Wenqiao Zang et al.

MOLECULAR CANCER (2015)

Article Biochemistry & Molecular Biology

Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits

Elena Ivanova et al.

NUCLEIC ACIDS RESEARCH (2015)

Editorial Material Multidisciplinary Sciences

Balancing copy number in ribosomal DNA

John H. Malone

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

miR-15b/16-2 deletion promotes B-cell malignancies

Francesca Lovat et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

A deeply conserved, noncanonical miRNA hosted by ribosomal DNA

Li-Ling Chak et al.

Review Biochemistry & Molecular Biology

Targeting the nucleolus for cancer intervention

Jaclyn E. Quin et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Article Oncology

Identification of novel fusion genes with 28S ribosomal DNA in hematologic malignancies

Satoru Kobayashi et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2014)

Article Biochemistry & Molecular Biology

Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing

Holger Bierhoff et al.

MOLECULAR CELL (2014)

Article Biochemistry & Molecular Biology

pRNA NoRC-associated RNA of rRNA operons

Stefanie Wehner et al.

RNA BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

Jeannine Diesch et al.

CELL AND BIOSCIENCE (2014)

Review Cell Biology

RB1 in cancer: Different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis

Riccardo Di Fiore et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Analysis of genome instability in breast cancer

Eldamaria de Vargas Wolfgramm et al.

MOLECULAR BIOLOGY REPORTS (2013)

Article Biochemistry & Molecular Biology

A Role for Small RNAs in DNA Double-Strand Break Repair

Wei Wei et al.

Review Biochemistry & Molecular Biology

MYC on the Path to Cancer

Chi V. Dang

Article Oncology

Nucleolar exit of RNF8 and BRCA1 in response to DNA damage

Marta Guerra-Rebollo et al.

EXPERIMENTAL CELL RESEARCH (2012)

Article Biochemistry & Molecular Biology

Immobilization of Proteins in the Nucleolus by Ribosomal Intergenic Spacer Noncoding RNA

Timothy E. Audas et al.

MOLECULAR CELL (2012)

Article Oncology

On the presence and role of human gene-body DNA methylation

Daudi Jjingo et al.

ONCOTARGET (2012)

Article Biotechnology & Applied Microbiology

Alu distribution and mutation types of cancer genes

Wensheng Zhang et al.

BMC GENOMICS (2011)

Review Biochemistry & Molecular Biology

Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast

Takehiko Kobayashi

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Article Biochemistry & Molecular Biology

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

Gretchen Poortinga et al.

NUCLEIC ACIDS RESEARCH (2011)

Review Genetics & Heredity

Genome organization in and around the nucleolus

Attila Nemeth et al.

TRENDS IN GENETICS (2011)

Article Biochemistry & Molecular Biology

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

Kaspar Burger et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Identification of miR-145 and miR-146a as mediators of the 5q-syndrome phenotype

Daniel T. Starczynowski et al.

NATURE MEDICINE (2010)

Article Multidisciplinary Sciences

Abundance of Ribosomal RNA Gene Copies Maintains Genome Integrity

Satoru Ide et al.

SCIENCE (2010)

Review Oncology

All y'all need to know 'bout retroelements in cancer

Victoria P. Belancio et al.

SEMINARS IN CANCER BIOLOGY (2010)

Letter Oncology

About the c.156_157insAlu BRCA2 breast cancer predisposing mutation

Erik Teugels et al.

BREAST CANCER RESEARCH AND TREATMENT (2009)

Article Oncology

Human rRNA Gene Clusters Are Recombinational Hotspots in Cancer

Dawn M. Stults et al.

CANCER RESEARCH (2009)

Article Oncology

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

Denis Drygin et al.

CANCER RESEARCH (2009)

Review Cell Biology

What the nucleolus says to a tumour pathologist

Massimo Derenzini et al.

HISTOPATHOLOGY (2009)

Article Multidisciplinary Sciences

qiRNA is a new type of small interfering RNA induced by DNA damage

Heng-Chi Lee et al.

NATURE (2009)

Article Biochemistry & Molecular Biology

c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells

C-N Shiue et al.

ONCOGENE (2009)

Article Multidisciplinary Sciences

Modulation of Gene Expression by Human Cytosolic tRNase ZL through 5′-Half-tRNA

Reyad A. Elbarbary et al.

PLOS ONE (2009)

Article Multidisciplinary Sciences

Ribosomal DNA contributes to global chromatin regulation

Silvana Paredes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

MicroRNAs with a nucleolar location

Joan C. Ritland Politz et al.

Review Pathology

Nucleolus, ribosomes, and cancer

Lorenzo Montanaro et al.

AMERICAN JOURNAL OF PATHOLOGY (2008)

Article Biochemistry & Molecular Biology

Inhibition of nucleolar transcription as a trigger for neuronal apoptosis

K. Kalita et al.

JOURNAL OF NEUROCHEMISTRY (2008)

Review Cell Biology

Nucleolus: the fascinating nuclear body

Valentina Sirri et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Genomic architecture and inheritance of human ribosomal RNA gene clusters

Dawn M. Stults et al.

GENOME RESEARCH (2008)

Article Immunology

Alu elements mediate MYB gene tandem duplication in human T-ALL

Jennifer O'Neil et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Biochemistry & Molecular Biology

Biological functions of DNA methyltransferase 1 require its methyltransferase activity

Marc Damelin et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Genetics & Heredity

Human genomic deletions mediated by recombination between Alu elements

Shurjo K. Sen et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2006)

Review Oncology

Divorcing ARF and p53: an unsettled case

Charles J. Sherr

NATURE REVIEWS CANCER (2006)

Article Biochemistry & Molecular Biology

p53-dependent transcriptional repression of c-myc is required for G(1) cell cycle arrest

JSL Ho et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Article Genetics & Heredity

In situ analyses of genome instability in breast cancer

K Chin et al.

NATURE GENETICS (2004)

Review Oncology

The RB and p53 pathways in cancer

CJ Sherr et al.

CANCER CELL (2002)

Article Biochemistry & Molecular Biology

Repression of RNA polymerase I transcription by the tumor suppressor p53

WG Zhai et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Article Oncology

Hypermethylation of ribosomal DNA in human breast carcinoma

PS Yen et al.

BRITISH JOURNAL OF CANCER (2000)