期刊
CELLS
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cells11030527
关键词
colorectal cancer; whole exome sequence; polygenic risk score; metabolomic profiling
类别
资金
- Ministry of Science and Technology [MOST 109-2314-B-037-035, MOST 109-2314-B-037-040, MOST 109-2314-B-037-046-MY3, MOST110-2314-B-037-097]
- Ministry of Health and Welfare [MOHW107-TDU-B-212-123006, MOHW107-TDU-B-212-114026B, MOHW108-TDU-B-212-133006, MOHW109-TDU-B-212-134026, MOHW109-TDU-B-212-114006, MOHW110-TDU-B-212-1140026]
- Kaohsiung Medical University Hospital [KMUH-DK(C)110010, KMUH110-0R37, KMUH-DK(B)110004-3, KMUH110-0R38, KMUH110-0M34, KMUH110-0M35, KMU-TC109B05, S109036]
- KMU Center for Cancer Research [KMUHSA11013]
- KMU Center for Liquid Biopsy
- Cohort Research Center Grant [110010]
- KMU Office for Industry-Academic Collaboration [KMU-TC109A04-1]
- Grant of Taiwan Precision Medicine Initiative, Academia Sinica, Taiwan, R.O.C.
- [KMUH110-0M36]
This study comprehensively analyzed the genomes of Taiwanese patients with CRC and observed significant genomic differences related to the site of CRC development. Blood metabolomic profiling and polygenic risk score analysis provided potential biomarkers for the early identification and prevention of CRC in the Taiwanese population.
Colorectal cancer (CRC) is the third most common cancer worldwide. The incidence and mortality rates of CRC are significantly higher in Taiwan than in other developed countries. Genes involved in CRC tumorigenesis differ depending on whether the tumor occurs on the left or right side of the colon, and genomic analysis is a keystone in the study and treatment of CRC subtypes. However, few studies have focused on the genetic landscape of Taiwanese patients with CRC. This study comprehensively analyzed the genomes of 141 Taiwanese patients with CRC through whole-exome sequencing. Significant genomic differences related to the site of CRC development were observed. Blood metabolomic profiling and polygenic risk score analysis were performed to identify potential biomarkers for the early identification and prevention of CRC in the Taiwanese population. Our findings provide vital clues for establishing population-specific treatments and health policies for CRC prevention in Taiwan.
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