4.6 Article

Driver Genetic Mutations in Spinal Cord Gliomas Direct the Degree of Functional Impairment in Tumor-Associated Spinal Cord Injury

期刊

CELLS
卷 10, 期 10, 页码 -

出版社

MDPI
DOI: 10.3390/cells10102525

关键词

glioma; spinal cord astrocytoma; diffuse midline glioma; genetic; mutation; IDH

资金

  1. Japan Society for the Promotion of Science (JSPS) [19K09453]
  2. Japan Society for the Promotion of Science [20K17962]
  3. Grants-in-Aid for Scientific Research [19K09453, 20K17962] Funding Source: KAKEN

向作者/读者索取更多资源

Genetic mutations, including IDH and H3F3A mutations, play a significant role in the functional prognosis of spinal cord gliomas. Grade I and II gliomas tend to show improved functional outcomes after surgery, while grade III/IV gliomas may experience deterioration. Spinal glioma progenitor cells with H3F3A mutations are associated with accelerated tumor-related spinal cord injury and functional impairment, whereas the presence of IDH mutations suggests a relatively favorable functional prognosis.
Genetic analysis in glioma has been developed recently. Spinal cord glioma is less common than intracranial glioma. Thus, the clinical significance of genetic mutations in spinal cord gliomas remains unclear. Furthermore, because the spinal cord is an important communication channel between the brain and the rest of the body, increased attention should be paid to its functional prognosis. In this study, we investigated the functional prognosis and driver genetic mutations in eight patients with spinal cord gliomas (World Health Organization grade I, three cases; grade II, two cases; grade III/IV, three cases). IDH mutations were detected in all grade II cases and H3F3A mutations were detected in all grade III/IV cases. The functional status of grade I and II gliomas remained unchanged or improved 1 year after surgery, whereas grade III/IV gliomas remained unchanged or deteriorated. Spinal glioma progenitor cells with H3F3A mutations were associated with accelerated tumor-associated spinal cord injury, which led to functional impairment. Conversely, the presence of IDH mutations, which are rarely reported in spinal gliomas, indicated a relatively favorable functional prognosis.

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