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Inflammaging, an Imbalanced Immune Response That Needs to Be Restored for Cancer Prevention and Treatment in the Elderly

CELLS (2021)

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Article Hematology

Preclinical development of a humanized chimeric antigen receptor against B-cell maturation antigen for multiple myeloma

Lorena Perez-Amill et al.

Summary: This study developed CAR-T cells targeting multiple myeloma, with ARI2h cells showing superior therapeutic efficacy compared to ARI2m cells, especially in cases with high tumor burden disease. The humanization of the single chain variable fragment and large-scale expansion of CAR-T cells set the groundwork for a clinical trial to evaluate the efficacy of ARI2h cell treatment for multiple myeloma patients.

HAEMATOLOGICA (2021)

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Article Oncology

miR-21 antagonism abrogates Th17 tumor promoting functions in multiple myeloma

Marco Rossi et al.

Summary: The study demonstrated that miR-21 plays a crucial role in Th17-mediated tumor growth and bone disease in multiple myeloma, with inhibition of miR-21 leading to reduced pathology. Early inhibition of miR-21 in T cells (miR-21i-T cells) was found to impair Th17 differentiation, thereby decreasing MM cell proliferation and osteoclast activity.

LEUKEMIA (2021)

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Article Immunology

Single-cell profiling reveals the trajectories of natural killer cell differentiation in bone marrow and a stress signature induced by acute myeloid leukemia

Adeline Crinier et al.

Summary: NK cells in human bone marrow can be classified into three subpopulations, with NK0 cells believed to be precursors of circulating CD56(dim) NK1-like NK cells and CD56(bright) NK2-like NK cells under physiological conditions. Transcriptomic analysis showed stress-induced repression of NK cell effector functions in bone marrow NK cells from patients with acute myeloid leukemia (AML), with reduced levels of CD160, but higher survival rates in the CD160(high) group.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

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Review Oncology

Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies

Nathalie Michels et al.

Summary: This study conducts a systematic review and meta-analysis to explore the association between chronic inflammation and cancer incidence. It finds that specific inflammatory markers like CRP, fibrinogen, and IL6 are related to certain cancer types such as breast, colorectal, and lung cancer. Improvements in study quality could be made by verifying inflammatory status, adjusting for confounders, and ensuring long-term follow-up.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2021)

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Article Immunology

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Denis A. Mogilenko et al.

Summary: This study characterized age-associated alterations in immune cells across multiple mouse organs and identified a distinct population of age-associated GZMK-expressing CD8(+) T cells. These Taa cells, highly clonal with specific features, were found to be a potential target to address age-associated dysfunctions of the immune system. In humans, proportions of the circulating GZMK(+) CDE3(+) T cell population that shares signatures with mouse Taa cells also increased during healthy aging.

IMMUNITY (2021)

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Article Rheumatology

A systematic review and meta-analysis to inform cancer screening guidelines in idiopathic inflammatory myopathies

Alexander G. S. Oldroyd et al.

Summary: Clinical factors associated with increased and decreased cancer risk in IIM patients were identified through systematic literature review and meta-analysis. Factors such as DM subtype, older age, male sex, dysphagia, cutaneous ulceration, and anti-transcriptional intermediary factor were found to increase cancer risk, while factors like PM subtype, Raynaud's phenomenon, interstitial lung disease, high serum creatine kinase or lactate dehydrogenase levels, and certain autoantibody positivity were associated with reduced cancer risk. Additionally, limited evidence suggested that CT scanning could be effective for cancer screening in IIM patients, highlighting the need for further research and consensus guidelines.

RHEUMATOLOGY (2021)

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Article Immunology

Thymic atrophy creates holes in Treg-mediated immuno-regulation via impairment of an antigen-specific clone

Rachel Thomas et al.

Summary: Age-related thymic atrophy reduces the output of naive conventional T cells, but does not affect the generation of pan-Treg cells. Specific tissue-specific Treg clones may experience abnormal agonist selection due to thymic atrophy, which combined with enhanced pan-pTreg cells, can significantly contribute to age-related chronic inflammation in the elderly.

IMMUNOLOGY (2021)

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Article Cell Biology

Protectin DX restores Treg/Th17 cell balance in rheumatoid arthritis by inhibiting NLRP3 inflammasome via miR-20a

Shengwei Jin et al.

Summary: Protectin DX (PDX) was found to effectively ameliorate the progression of collagen-induced arthritis by restoring Treg/T(h)17 cell balance, and this effect was mediated by inhibiting the NLRP3 inflammasome pathway via miR-20a.

CELL DEATH & DISEASE (2021)

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Review Immunology

Decidual Natural Killer Cells: A Good Nanny at the Maternal-Fetal Interface During Early Pregnancy

Yuefang Liu et al.

Summary: This review discusses the important roles of decidual natural killer (dNK) cells in pregnancy, highlighting their generation, subsets, surface or soluble molecules, and functions crucial for maintaining pregnancy. It also explores the new functions of dNK cells, such as controlled cytotoxicity, immunosurveillance, and immunotrophism, and the molecular mechanisms involved in these functions, emphasizing their potential clinical applications.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Reprogramming Immune Cells for Enhanced Cancer Immunotherapy: Targets and Strategies

Yan Dong et al.

Summary: This article summarizes the central roles of immune cells in tumor progression and regression, as well as existing and emerging strategies for immune cell-based immunotherapies for different types of cancer. Furthermore, it discusses current challenges and potential solutions in translating these immunotherapies into clinical practice.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Cell Biology

IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7

Jiwei Wang et al.

Summary: The study reveals that IL-6 activates the TLR2, TLR4, and AKT pathways, inhibits the expression of beta-catenin and Setd7, and promotes proinflammatory gene expression in BMSCs. Setd7 expression in bone tissues of aged mice is suppressed, but it can promote BMSC osteogenic differentiation.

ACTA HISTOCHEMICA (2021)

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Shuhang Wang et al.

Summary: TIL therapy involves harvesting, culturing, and infusing infiltrated lymphocytes from tumors, offering unique advantages in treating solid tumors, yet facing limitations in its current applications.

BMC MEDICINE (2021)

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Hallmarks of aging and immunosenescence: Connecting the dots

Leane Perim Rodrigues et al.

Summary: Aging is a natural physiological process that leads to various challenges due to cell senescence, which can have negative consequences for health. Immunosenescence, as a result of aging, alters the functionality of the immune system.

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Article Geriatrics & Gerontology

The elevated level of IL-1? in the bone marrow of aged mice leads to MSC senescence partly by down-regulating Bmi-1

Xueling Zheng et al.

Summary: Osteoporosis is more prevalent as individuals age due to bone marrow mesenchymal stem cells (MSCs) undergoing senescence, resulting in reduced bone formation and repair. Studies showed that MSCs from aged mice exhibited senescent phenotypes with decreased Bmi-1 expression and increased IL-1β levels in the bone marrow microenvironment, leading to MSC senescence.

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Article Immunology

Interleukin-17 induces pyroptosis in osteoblasts through the NLRP3 inflammasome pathway in vitro

Lihong Lei et al.

Summary: This study demonstrated that high concentration IL-17 may induce pyroptosis of osteoblasts, leading to impaired proliferation and function, as well as the release of IL1 beta and RANKL, contributing to bone metabolism disruption. The NLRP3 inflammasome pathway was found to be involved in the pyroptosis of osteoblasts.

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High-dimensional mass cytometry analysis of NK cell alterations in AML identifies a subgroup with adverse clinical outcome

Anne-Sophie Chretien et al.

Summary: The accumulation of CD56(-)CD16(+) unconventional NK cells in patients with acute myeloid leukemia may be a consequence of immune escape from innate immunity during AML progression.

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Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer

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The Hematopoietic Bone Marrow Niche Ecosystem

Julia Froebel et al.

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Thais Helena Gasparoto et al.

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Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis

Marcela Garzon-Tituana et al.

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Article Biochemistry & Molecular Biology

Leptin facilitates the differentiation of Th17 cells from MRL/Mp-Fas lpr lupus mice by activating NLRP3 inflammasome

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INNATE IMMUNITY (2020)

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Review Cell Biology

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JOURNAL OF CELLULAR PHYSIOLOGY (2020)

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Successful aging: insights from proteome analyses of healthy centenarians

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AGING-US (2020)

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Article Oncology

A Unique Role of T Helper 17 Cells in Different Treatment Stages of Multiple Myeloma

TingTing Ma et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2020)

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Article Immunology

CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors

Haiping Wang et al.

NATURE IMMUNOLOGY (2020)

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Article Medicine, General & Internal

Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors

Enli Liu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Review Hematology

The role of regulatory T cells in graft-versus-host disease management

Jennifer S. Whangbo et al.

EXPERT REVIEW OF HEMATOLOGY (2020)

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Article Immunology

Gasdermin E-mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

Yuying Liu et al.

SCIENCE IMMUNOLOGY (2020)

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Letter Biophysics

Machine learning applied to gene expression analysis of T-lymphocytes in patients with cGVHD

Juana Serrano-Lopez et al.

BONE MARROW TRANSPLANTATION (2020)

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Article Cell Biology

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Leena P. Bharath et al.

CELL METABOLISM (2020)

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CD4+ T Cells at the Center of Inflammaging

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CELL METABOLISM (2020)

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A proteomic atlas of senescence-associated secretomes for aging biomarker development

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PLOS BIOLOGY (2020)

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Review Geriatrics & Gerontology

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Rachel Thomas et al.

IMMUNITY & AGEING (2020)

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Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

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SCIENCE (2020)

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Article Immunology

Point-Of-Care CAR T-Cell Production (ARI-0001) Using a Closed Semi-automatic Bioreactor: Experience From an Academic Phase I Clinical Trial

Maria Castella et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Cell Biology

The Immune Response Against Human Cytomegalovirus Links Cellular to Systemic Senescence

John J. Heath et al.

CELLS (2020)

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Review Biochemistry & Molecular Biology

Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword

Anthony M. Battram et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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FRONTIERS IN ENDOCRINOLOGY (2020)

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CELLS (2020)

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Myeloma cells induce the accumulation of activated CD94low NK cells by cell-to-cell contacts involving CD56 molecules

Chiara Barberi et al.

BLOOD ADVANCES (2020)

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Mechanisms of NLRP3 priming in inflammaging and age related diseases

Anna Gritsenko et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

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Regulatory T cells suppress Th17 cell Ca2+ signaling in the spinal cord during murine autoimmune neuroinflammation

Shivashankar Othy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Extracellular Granzyme A Promotes Colorectal Cancer Development by Enhancing Gut Inflammation

Llipsy Santiago et al.

CELL REPORTS (2020)

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Article Geriatrics & Gerontology

Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience

Alexey Moskalev et al.

AGING AND DISEASE (2020)

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Natural Killer Cells in Immunotherapy: Are We Nearly There?

Mireia Bachiller et al.

CANCERS (2020)

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Lu Wang et al.

EUROPEAN JOURNAL OF CLINICAL NUTRITION (2019)

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Letter Hematology

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

Daniel A. Pollyea et al.

HAEMATOLOGICA (2019)

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c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host-microbiota homeostasis

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NATURE IMMUNOLOGY (2019)

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Regulatory T cells in cancer immunosuppression - implications for anticancer therapy

Yosuke Togashi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Review Immunology

Features of Human Decidual NK Cells in Healthy Pregnancy and During Viral Infection

Nabila Jabrane-Ferrat

FRONTIERS IN IMMUNOLOGY (2019)

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The relation between systemic inflammation and incident cancer in patients with stable cardiovascular disease: a cohort study

Cilie C. Van't Klooster et al.

EUROPEAN HEART JOURNAL (2019)

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Article Biochemistry & Molecular Biology

NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation

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JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor

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JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

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BLOOD (2019)

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Article Cell Biology

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

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CELL METABOLISM (2019)

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Granzyme K Expressed by Classically Activated Macrophages Contributes to Inflammation and Impaired Remodeling

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JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Review Immunology

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TRENDS IN IMMUNOLOGY (2019)

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Review Endocrinology & Metabolism

Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma

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Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer

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JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Multidisciplinary Sciences

Circulating CD56bright NK cells inversely correlate with survival of melanoma patients

Kaat de Jonge et al.

SCIENTIFIC REPORTS (2019)

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Article Immunology

Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging

Robert A. Campbell et al.

JOURNAL OF IMMUNOLOGY (2018)

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Review Cell Biology

Inflammageing and metaflammation: The yin and yang of type 2 diabetes

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AGEING RESEARCH REVIEWS (2018)

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NK cells in autoimmune diseases: Linking innate and adaptive immune responses

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AUTOIMMUNITY REVIEWS (2018)

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Influence of Age on Acute and Chronic GVHD in Children Undergoing HLA-Identical Sibling Bone Marrow Transplantation for Acute Leukemia: Implications for Prophylaxis

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BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION (2018)

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Th17, synchronically increased with Tregs and Bregs, promoted by tumour cells via cell-contact in primary hepatic carcinoma

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CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)

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The Balance of Th17 versus Treg Cells in Autoimmunity

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Biochemistry & Molecular Biology

Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells

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NATURE MEDICINE (2018)

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Article Geriatrics & Gerontology

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IMMUNITY & AGEING (2018)

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PLOS ONE (2018)

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TURKISH JOURNAL OF HEMATOLOGY (2018)

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NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

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NATURE COMMUNICATIONS (2018)

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Oncotarget (2018)

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INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

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Review Hematology

Mechanistic approaches for the prevention and treatment of chronic GVHD

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BLOOD (2017)

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Review Geriatrics & Gerontology

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GERONTOLOGY (2017)

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Article Immunology

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IMMUNITY (2017)

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Review Biochemistry & Molecular Biology

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

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T cells in multiple myeloma display features of exhaustion and senescence at the tumor site

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IL-35 Over-expression is Associated with Genesis of Gastric Cancer

Yong-Gang Fan et al.

Asian Pacific Journal of Cancer Prevention (2015)

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Article Immunology

CD56brightCD16- NK Cells Produce Adenosine through a CD38-Mediated Pathway and Act as Regulatory Cells Inhibiting Autologous CD4+ T Cell Proliferation

Fabio Morandi et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Immunology

Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation

Brandon D. Coder et al.

JOURNAL OF IMMUNOLOGY (2015)

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Article Nutrition & Dietetics

Diet and Inflammation: Possible Effects on Immunity, Chronic Diseases, and Life Span

Camillo Ricordi et al.

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (2015)

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Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

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Review Rheumatology

Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort

Gerd Cecilie Dobloug et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2015)

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Article Biochemistry & Molecular Biology

Transmissible cytotoxicity of multiple myeloma cells by cord blood-derived NK cells is mediated by vesicle trafficking

B. Martin-Antonio et al.

CELL DEATH AND DIFFERENTIATION (2015)

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Article Geriatrics & Gerontology

Aging and the Burden of Multimorbidity: Associations With Inflammatory and Anabolic Hormonal Biomarkers

Elisa Fabbri et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2015)

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Editorial Material Biochemistry & Molecular Biology

Geroscience: Linking Aging to Chronic Disease

Brian K. Kennedy et al.

CELL (2014)

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Review Biochemistry & Molecular Biology

Granzyme M: behind enemy lines

S. A. H. de Poot et al.

CELL DEATH AND DIFFERENTIATION (2014)

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Review Immunology

Shaping of NK cell subsets by aging

Rafael Solana et al.

CURRENT OPINION IN IMMUNOLOGY (2014)

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Article Geriatrics & Gerontology

Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression

Mi-Ae Lim et al.

EXPERIMENTAL GERONTOLOGY (2014)

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Article Geriatrics & Gerontology

Immune parameters identify Italian centenarians with a longer five-year survival independent of their health and functional status

L. Bucci et al.

EXPERIMENTAL GERONTOLOGY (2014)

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Review Geriatrics & Gerontology

Regulatory T Cells and the Immune Aging Process: A Mini-Review

Ann Jagger et al.

GERONTOLOGY (2014)

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Article Hematology

Leukemia-induced phenotypic and functional defects in natural killer cells predict failure to achieve remission in acute myeloid leukemia

Kate Stringaris et al.

HAEMATOLOGICA (2014)

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Article Geriatrics & Gerontology

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Claudio Franceschi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

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Review Medicine, Research & Experimental

Animal models of gastrointestinal inflammation and cancer

L. Lu et al.

LIFE SCIENCES (2014)

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Review Cell Biology

Cellular senescence: from physiology to pathology

Daniel Munoz-Espin et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

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Article Cell Biology

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

Fei Zheng et al.

MEDIATORS OF INFLAMMATION (2014)

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Article Oncology

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

Tomer Cooks et al.

CANCER CELL (2013)

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Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

CELL (2013)

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Article Geriatrics & Gerontology

The Th17/Treg balance is disturbed during aging

Vanessa Schmitt et al.

EXPERIMENTAL GERONTOLOGY (2013)

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Editorial Material Cell Biology

Transmitting senescence to the cell neighbourhood

Matthew Hoare et al.

NATURE CELL BIOLOGY (2013)

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Article Cell Biology

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

Juan Carlos Acosta et al.

NATURE CELL BIOLOGY (2013)

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Article Biochemistry & Molecular Biology

Granule exocytosis mediates immune surveillance of senescent cells

A. Sagiv et al.

ONCOGENE (2013)

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Article Multidisciplinary Sciences

Antigen Presenting Cell-Mediated Expansion of Human Umbilical Cord Blood Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity

Nina Shah et al.

PLOS ONE (2013)

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Article Cell Biology

Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells

Lishi Sun et al.

AGING CELL (2012)

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Article Endocrinology & Metabolism

Immunoregulatory Natural Killer Cells Suppress Autoimmunity by Down-Regulating Antigen-Specific CD8+ T Cells in Mice

Margret Ehlers et al.

ENDOCRINOLOGY (2012)

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Article Multidisciplinary Sciences

Natural killer cells act as rheostats modulating antiviral T cells

Stephen N. Waggoner et al.

NATURE (2012)

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Article Multidisciplinary Sciences

Increased T Regulatory Cells Are Associated with Adverse Clinical Features and Predict Progression in Multiple Myeloma

Karthick Raja Muthu Raja et al.

PLOS ONE (2012)

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Article Pathology

Regulatory T-Cells: Diverse Phenotypes Integral to Immune Homeostasis and Suppression

Richard A. Peterson

TOXICOLOGIC PATHOLOGY (2012)

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Article Oncology

Skewed immunological balance between Th17 (CD4+IL17A+) and Treg (CD4+CD25+FOXP3+) cells in human oral squamous cell carcinoma

Poonam Gaur et al.

CELLULAR ONCOLOGY (2012)

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Article Cell Biology

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

Yun-Hee Youm et al.

CELL REPORTS (2012)

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Review Hematology

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

Charles A. Dinarello

BLOOD (2011)

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Article Oncology

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

Marie Tosolini et al.

CANCER RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

CELL (2011)

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Article Medicine, Research & Experimental

A dual role for the immune response in a mouse model of inflammation-associated lung cancer

Michael Dougan et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

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Article Hematology

A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma

Kimberly Noonan et al.

BLOOD (2010)

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Article Hematology

Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma

Rao H. Prabhala et al.

BLOOD (2010)

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Article Oncology

Cancer Statistics, 2010

Ahmedin Jemal et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2010)

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Article Oncology

Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation

Hiroyuki Takahashi et al.

CANCER CELL (2010)

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Review Biochemistry & Molecular Biology

Immunity, Inflammation, and Cancer

Sergei I. Grivennikov et al.

CELL (2010)

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Article Cell Biology

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

Rinke Stienstra et al.

CELL METABOLISM (2010)

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Review Immunology

Stem cells and the aging hematopoietic system

Isabel Beerman et al.

CURRENT OPINION IN IMMUNOLOGY (2010)

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Article Immunology

A Role for Granzyme M in TLR4-Driven Inflammation and Endotoxicosis

Desiree A. Anthony et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Multidisciplinary Sciences

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell et al.

NATURE (2010)

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Article Immunology

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1 beta in type 2 diabetes

Seth L. Masters et al.

NATURE IMMUNOLOGY (2010)

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Review Hematology

Genomic polymorphisms of the innate immune system and allogeneic stem cell transplantation

Beatriz Martin-Antonio et al.

EXPERT REVIEW OF HEMATOLOGY (2010)

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Article Hematology

Obesity accelerates thymic aging

Hyunwon Yang et al.

BLOOD (2009)

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Article Oncology

Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis

Katriina Heikkilae et al.

CANCER CAUSES & CONTROL (2009)

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Review Immunology

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes

Markus Feuerer et al.

NATURE IMMUNOLOGY (2009)

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Article Multidisciplinary Sciences

Nitric oxide and TNF-α trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice

S. E. Erdman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Review Immunology

Colitis-associated cancer: the role of T cells in tumor development

Maximilian J. Waldner et al.

SEMINARS IN IMMUNOPATHOLOGY (2009)

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Article Hematology

Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

Kavita M. Dhodapkar et al.

BLOOD (2008)

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Article Immunology

Ageing is associated with diminished apoptotic cell clearance in vivo

T. Aprahamian et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2008)

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Review Immunology

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation

Celine S. Lages et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Cell Biology

The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age

Rita Simone et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2008)

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Review Multidisciplinary Sciences

Cancer-related inflammation

Alberto Mantovani et al.

NATURE (2008)

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Article Immunology

Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells

L. Airas et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2008)

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Article Multidisciplinary Sciences

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

Wen Xue et al.

NATURE (2007)

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Article Hematology

Deficient expression of NCR in NK cells from acute myeloid leukemia: evolution during leukemia treatment and impact of leukemia cells in NCRdull phenotype induction

Cyril Fauriat et al.

BLOOD (2007)

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Article Cell Biology

Accumulation of senescent cells in mitotic tissue of aging primates

Jessie C. Jeyapalan et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2007)

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Article Cell Biology

Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans

Claudio Franceschi et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2007)

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Article Immunology

High accumulation of T regulatory cells prevents the activation of immune responses in aged animals

Sanjay Sharma et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Biochemistry & Molecular Biology

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

Jacob Hanna et al.

NATURE MEDICINE (2006)

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Article Environmental Sciences

Correlation of in vitro cytokine responses with the chemical composition of soil-derived particulate matter

JM Veranth et al.

ENVIRONMENTAL HEALTH PERSPECTIVES (2006)

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Article Hematology

Dysfunctional T regulatory cells in multiple myeloma

RH Prabhala et al.

BLOOD (2006)

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Article Immunology

Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes

B Bade et al.

INTERNATIONAL IMMUNOLOGY (2005)

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Article Immunology

The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age

R Gregg et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2005)

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Article Respiratory System

Role of inflammation in mouse lung tumorigenesis: A review

AM Malkinson

EXPERIMENTAL LUNG RESEARCH (2005)

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Article Oncology

Rapid turnover of the CD8+CD28- T-cell subset of effector cells in the circulation of patients with head and neck cancer

T Tsukishiro et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2003)

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Article Oncology

Cigarette smoke exposure increases ulcerative colitis-associated colonic adenoma formation in mice

ESL Liu et al.

CARCINOGENESIS (2003)

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Article Immunology

Deficiencies of GM-CSF and interferon γ link inflammation and cancer

T Enzler et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

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Article Immunology

CD4+CD25- T cells in aged mice are hyporesponsive and exhibit suppressive activity

J Shimizu et al.

JOURNAL OF IMMUNOLOGY (2003)

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