期刊
CELLS
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/cells11040669
关键词
cardiovascular risk; osteopontin; coronary artery disease; inflammation; neutrophil
类别
资金
- Rete Cardiologica of Italian Ministry of Health [2754291]
- Fondazione Carige
Inflammation may play a role in the development of coronary artery disease (CAD) in different cardiovascular risk factor categories. Osteopontin (OPN) levels were highest in the low risk factor group and associated with CAD. Other biomarkers, such as myeloperoxidase (MPO) and resistin, did not differ based on CAD presence.
Stratification according high cardiovascular (CV) risk categories, still represents a clinical challenge. In this analysis of the CAPIRE study (NCT02157662), we investigate whether inflammation could fit between CV risk factors (RFs) and the presence of coronary artery disease (CAD). In total, 544 patients were included and categorized according with the presence of CAD and CV risk factor burden (low/multiple). The primary endpoint was to verify any independent association of neutrophil-related biomarkers with CAD across CV risk categories. The highest values of osteopontin (OPN) were detected in the low RF group and associated with CAD (23.2 vs. 19.4 ng/mL; p = 0.001), although no correlation with plaque extent and/or composition were observed. Conversely, myeloperoxidase (MPO) and resistin did not differ by CAD presence. Again, OPN was identified as independent variable associated with CAD but only in the low RF group (adjOR 8.42 [95% CI 8.42-46.83]; p-value = 0.015). As an ancillary finding, a correlation linked OPN with the neutrophil degranulation biomarker MPO (r = 0.085; p = 0.048) and resistin (r = 0.177; p = 3.4 x 10(-5)). In the present study, OPN further strengthens its role as biomarker of CAD, potentially bridging subclinical CV risk with development of atherosclerosis.
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