Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

The cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phase. Cell cycle progression is mediated by cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits. However, the driving force of cell cycle progression is growth factor-initiated signaling pathways that control the activity of various Cdk-cyclin complexes. While the mechanism underlying the role of growth factor signaling in G1 phase of cell cycle progression has been largely revealed due to early extensive research, little is known regarding the function and mechanism of growth factor signaling in regulating other phases of the cell cycle, including S, G2, and M phase. In this review, we briefly discuss the process of cell cycle progression through various phases, and we focus on the role of signaling pathways activated by growth factors and their receptor (mostly receptor tyrosine kinases) in regulating cell cycle progression through various phases.

Automated summary

The cell cycle is a series of events driving cell division and production of two new daughter cells, involving phases G1, S, G2, and M. Progression is mediated by Cdks and their cyclin subunits, but growth factor signaling pathways are the driving force. Role of growth factor signaling in phases other than G1 is still poorly understood, with research focusing on regulation of cell cycle progression through different phases.