4.6 Review

Regulation of Cell Cycle Progression by Growth Factor-Induced Cell Signaling

期刊

CELLS
卷 10, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/cells10123327

关键词

cell cycle; growth factors; receptor tyrosine kinases; G1 phase; S phase; G2 phase; M phase; Ras; Erk; PI3K; Akt

向作者/读者索取更多资源

The cell cycle is a series of events driving cell division and production of two new daughter cells, involving phases G1, S, G2, and M. Progression is mediated by Cdks and their cyclin subunits, but growth factor signaling pathways are the driving force. Role of growth factor signaling in phases other than G1 is still poorly understood, with research focusing on regulation of cell cycle progression through different phases.
The cell cycle is the series of events that take place in a cell, which drives it to divide and produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the following phases: G1, S, G2, and M phase. Cell cycle progression is mediated by cyclin-dependent kinases (Cdks) and their regulatory cyclin subunits. However, the driving force of cell cycle progression is growth factor-initiated signaling pathways that control the activity of various Cdk-cyclin complexes. While the mechanism underlying the role of growth factor signaling in G1 phase of cell cycle progression has been largely revealed due to early extensive research, little is known regarding the function and mechanism of growth factor signaling in regulating other phases of the cell cycle, including S, G2, and M phase. In this review, we briefly discuss the process of cell cycle progression through various phases, and we focus on the role of signaling pathways activated by growth factors and their receptor (mostly receptor tyrosine kinases) in regulating cell cycle progression through various phases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据