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Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
Jean-Francois Trempe et al.
SCIENCE (2013)
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
Yun Chen et al.
SCIENCE (2013)
Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging
Hyun-Woo Rhee et al.
SCIENCE (2013)
Mitochondrial Trafficking in Neurons
Thomas L. Schwarz
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
B. E. Riley et al.
NATURE COMMUNICATIONS (2013)
Following Ariadne's thread: a new perspective on RBR ubiquitin ligases
Dawn M. Wenzel et al.
BMC BIOLOGY (2012)
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
Andrew W. Greene et al.
EMBO REPORTS (2012)
TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy
Giichi Takaesu et al.
JOURNAL OF BIOCHEMISTRY (2012)
Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy
Rita A. Hanna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
Eisuke Itakura et al.
JOURNAL OF CELL SCIENCE (2012)
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
Lei Liu et al.
NATURE CELL BIOLOGY (2012)
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
Kei Okatsu et al.
NATURE COMMUNICATIONS (2012)
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
Kahori Shiba-Fukushima et al.
SCIENTIFIC REPORTS (2012)
Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes
Youngil Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2011)
ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding
Elaine A. Dunlop et al.
AUTOPHAGY (2011)
Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop
Antje S. Loeffler et al.
AUTOPHAGY (2011)
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Xinnan Wang et al.
CELL (2011)
PINK1 cleavage at position A103 by the mitochondrial protease PARL
Emma Deas et al.
HUMAN MOLECULAR GENETICS (2011)
Binding to Syntenin-1 Protein Defines a New Mode of Ubiquitin-based Interactions Regulated by Phosphorylation
Sundaresan Rajesh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking
Cathrin Meissner et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Novel Regulation of Parkin Function through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson's Disease
Syed Z. Imam et al.
JOURNAL OF NEUROSCIENCE (2011)
Parkin Interacts with Ambra1 to Induce Mitophagy
Cindy Van Humbeeck et al.
JOURNAL OF NEUROSCIENCE (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
Mechanisms of mitophagy
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
Libin Shang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan et al.
SCIENCE (2011)
Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
Philipp Wild et al.
SCIENCE (2011)
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
Hannah E. J. Polson et al.
AUTOPHAGY (2010)
A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression
Edward L. Huttlin et al.
CELL (2010)
Nix is a selective autophagy receptor for mitochondrial clearance
Ivana Novak et al.
EMBO REPORTS (2010)
Regulation of autophagy by phosphatidylinositol 3-phosphate
Chloe Burman et al.
FEBS LETTERS (2010)
Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
Matthew E. Gegg et al.
HUMAN MOLECULAR GENETICS (2010)
Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming
Wen-Xing Ding et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
Atsushi Tanaka et al.
JOURNAL OF CELL BIOLOGY (2010)
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
Seok Min Jin et al.
JOURNAL OF CELL BIOLOGY (2010)
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
Noriyuki Matsuda et al.
JOURNAL OF CELL BIOLOGY (2010)
The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
Angela C. Poole et al.
PLOS ONE (2010)
The Association of AMPK with ULK1 Regulates Autophagy
Jong Woo Lee et al.
PLOS ONE (2010)
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Cristofol Vives-Bauza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function
Han Seok Ko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
Derek P. Narendra et al.
PLOS BIOLOGY (2010)
Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration
Suzana Gispert et al.
PLOS ONE (2009)
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
Mondira Kundu et al.
BLOOD (2008)
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
Huafeng Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Elizabeth L. Axe et al.
JOURNAL OF CELL BIOLOGY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Olga Martins de Brito et al.
NATURE (2008)
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
Rachel L. Schweers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice
Abhinav Diwan et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
Eyal Avraham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis
Abhinav Diwan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Parkin-deficient mice are not a robust model of parkinsonism
FA Perez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation
Y Kabeya et al.
JOURNAL OF CELL SCIENCE (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Inducible Expression of BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes
KM Regula et al.
CIRCULATION RESEARCH (2002)
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
H Shimura et al.
NATURE GENETICS (2000)
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