Efferocytosis during Skeletal Muscle Regeneration

Efferocytosis, i.e., engulfment of dead cells by macrophages, is a crucial step during tissue repair after an injury. Efferocytosis delineates the transition from the pro-inflammatory phase of the inflammatory response to the recovery phase that ensures tissue reconstruction. We present here the role of efferocytosis during skeletal muscle regeneration, which is a paradigm of sterile tissue injury followed by a complete regeneration. We present the molecular mechanisms that have been described to control this process, and particularly the metabolic control of efferocytosis during skeletal muscle regeneration.

Automated summary

Efferocytosis, the engulfment of dead cells by macrophages, plays a crucial role in tissue repair post-injury by delineating the transition from the pro-inflammatory phase to the recovery phase. In the context of skeletal muscle regeneration, efferocytosis is essential for sterile tissue injury followed by complete regeneration, with molecular mechanisms and metabolic control playing a significant role in this process.