Co-Expression Analysis of microRNAs and Proteins in Brain of Alzheimer's Disease Patients

Alzheimer's disease (AD) is the most common form of dementia globally; however, the aetiology of AD remains elusive hindering the development of effective therapeutics. MicroRNAs (miRNAs) are regulators of gene expression and have been of growing interest in recent studies in many pathologies including AD not only for their use as biomarkers but also for their implications in the therapeutic field. In this study, miRNA and protein profiles were obtained from brain tissues of different stage (Braak III-IV and Braak V-VI) of AD patients and compared to matched controls. The aim of the study was to identify in the late stage of AD, the key dysregulated pathways that may contribute to pathogenesis and then to evaluate whether any of these pathways could be detected in the early phase of AD, opening new opportunity for early treatment that could stop or delay the pathology. Six common pathways were found regulated by miRNAs and proteins in the late stage of AD, with one of them (Rap1 signalling) activated since the early phase. MiRNAs and proteins were also compared to explore an inverse trend of expression which could lead to the identification of new therapeutic targets. These results suggest that specific miRNA changes could represent molecular fingerprint of neurodegenerative processes and potential therapeutic targets for early intervention.

Automated summary

Alzheimer's disease is the most common form of dementia globally, however, its cause is still unknown, hindering the development of effective treatments. Recent studies have found that MicroRNAs play an important role in Alzheimer's disease as regulators of gene expression, and could serve as biomarkers and potential therapeutic targets. This study identified six common pathways regulated by MicroRNAs and proteins, including one pathway that is activated in the early phase, providing opportunities for early intervention.