4.6 Review

The Role of Circular RNAs in DNA Damage Response and Repair

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Oleuropein is a natural inhibitor of PAI-1-mediated proliferation in human ER-/PR- breast cancer cells

Elena E. Tzekaki et al.

Summary: Elevated levels of PAI-1 are inversely correlated with ER and PR expressions in estrogen/progesterone-responsive human malignancies. In silico molecular docking analysis identified oleuropein as a potent PAI-1-binding molecule with increased affinity compared to other olive oil constituents. Oleuropein acts as a natural PAI-1 inhibitor by destabilizing PAI-1 levels selectively in ER-/PR- breast cancer cells, leading to downstream caspase activation and cell growth inhibition.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Article Biochemistry & Molecular Biology

Identification and Bioinformatic Assessment of circRNA Expression After RMI1 Knockdown and Ionizing Radiation Exposure

Yuxiao Sun et al.

Summary: RMI1 knockdown leads to increased radiosensitivity and apoptosis, with differentially expressed circRNAs identified in response to IR, indicating the important role of RMI1 in the cellular response to IR and the regulatory mechanism of circRNAs in the radiation response.

DNA AND CELL BIOLOGY (2021)

Article Oncology

Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway

Jiacheng Cao et al.

Summary: The study found that circLMO7 can promote the proliferation, migration, and invasion of gastric cancer cells by acting as a sponge for miR-30a-3p to affect the WNT2/beta-Catenin pathway. Animal experiments also showed that circLMO7 could promote gastric cancer growth and metastasis in vivo. Furthermore, circLMO7 can also impact the glutamine metabolism of gastric cancer cells through the WNT2/beta-Catenin pathway to enhance its malignant biological function.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Review Biochemistry & Molecular Biology

Non-Canonical Functions of the ARF Tumor Suppressor in Development and Tumorigenesis

Nefeli Lagopati et al.

Summary: P14ARF is a well-characterized tumor suppressor involved in regulating cell cycle arrest and apoptosis in response to oncogenic stimuli. It is frequently lost through methylation in a variety of human malignancies and has been linked to melanomas and glioblastomas through mutations and deletions. In addition to its role in tumorigenesis, P14ARF is also involved in developmental processes such as spermatogenesis, mammary gland development, ocular development, and angiogenesis.

BIOMOLECULES (2021)

Article Geriatrics & Gerontology

Restoration of BMI1 levels after the administration of early harvest extra virgin olive oil as a therapeutic strategy against Alzheimer's disease

Elena E. Tzekaki et al.

Summary: The study showed that administration of extra virgin olive oil to MCI patients for 12 months can increase BMI1 levels, reduce p53 levels, and normalize AD-related biomarkers. Additionally, EVOO treatment was associated with a decrease in oxidative stress and inflammatory responses.

EXPERIMENTAL GERONTOLOGY (2021)

Review Cell Biology

Cockayne Syndrome Group B (CSB): The Regulatory Framework Governing the Multifunctional Protein and Its Plausible Role in Cancer

Zoi Spyropoulou et al.

Summary: Cockayne syndrome is a DNA repair syndrome with symptoms like neurodegeneration and premature aging, mainly caused by mutations in the CSB gene. Besides its role in DNA repair pathways, CSB is also involved in DNA transcription, mitochondrial biology, telomere maintenance, and p53 regulation.
Review Biochemistry & Molecular Biology

The Role of RNA in DNA Breaks, Repair and Chromosomal Rearrangements

Matvey Mikhailovich Murashko et al.

Summary: Incorrect repair of DNA double-strand breaks leading to chromosomal rearrangements is a major cause of oncogenesis. Recent studies have highlighted the key role of various types of RNA in the formation, recognition, and repair of DSBs, with gene mutations or changes in RNA expression levels potentially leading to DNA repair defects and increased chromosome aberration frequency. Additionally, certain RNAs have been shown to stimulate long-range chromosomal rearrangements, and further research is needed to understand how RNA mediates specific chromosomal rearrangements.

BIOMOLECULES (2021)

Review Cell Biology

Regulatory and Functional Involvement of Long Non-Coding RNAs in DNA Double-Strand Break Repair Mechanisms

Angelos Papaspyropoulos et al.

Summary: Protection of genome integrity is crucial, and eukaryotes have developed NHEJ and HR pathways to repair DSBs. Recent research has identified non-coding RNAs, especially lncRNAs, as key players in these pathways with therapeutic potential.
Article Oncology

Circular RNA BMI1 Serves as a Potential Target for Diagnosis and Treatment in Esophageal Cancer

Qian Zhao et al.

Summary: The study revealed that the expression of circ-BMI1 is significantly down-regulated in esophageal cancer, and overexpression of circ-BMI1 can inhibit the proliferation, migration, and colony formation of Eca109 cells, as well as tumor growth in nude mice. These findings suggest that circ-BMI1 may be a potential target for diagnosis and treatment in esophageal cancer.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2021)

Review Biochemistry & Molecular Biology

Targeting circular RNAs as a therapeutic approach: current strategies and challenges

Alina T. He et al.

Summary: Significant progress has been made in circular RNA (circRNA) research in recent years. CircRNAs are considered potential therapeutic targets and can be manipulated through various strategies for gain-of-function or loss-of-function. Although still in the early stages, the CRISPR/Cas13 system shows promise in efficiently knocking down circRNAs.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Biochemistry & Molecular Biology

Identification of low-dose radiation-induced exosomal circ- METRN and miR-4709-3p/GRB14/PDGFRα pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance

Xinxin Wang et al.

Summary: This study reveals the significant role of low-dose radiation-induced exosomal circ-METRN in the progression and radioresistance of glioblastoma, providing valuable insights into potential therapeutic targets.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Neurosciences

The Landscape of Circular RNA Expression in the Human Brain

Akira Gokool et al.

BIOLOGICAL PSYCHIATRY (2020)

Review Medicine, Research & Experimental

circRNAs and Exosomes: A Mysterious Frontier for Human Cancer

Xuefei Shi et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Article Biochemistry & Molecular Biology

A Circular RNA from the MDM2 Locus Controls Cell Cycle Progression by Suppressing p53 Levels

Ritu Chaudhary et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Translation and functional roles of circular RNAs in human cancer

Ming Lei et al.

MOLECULAR CANCER (2020)

Review Neurosciences

Role of circular RNAs in brain development and CNS diseases

Suresh L. Mehta et al.

PROGRESS IN NEUROBIOLOGY (2020)

Review Cell Biology

Biogenesis and Functions of Circular RNAs Come into Focus

Mei-Sheng Xiao et al.

TRENDS IN CELL BIOLOGY (2020)

Article Cell Biology

DNA:RNA hybrids form at DNA double-strand breaks in transcriptionally active loci

Aldo S. Bader et al.

CELL DEATH & DISEASE (2020)

Review Pharmacology & Pharmacy

Modeling and Targeting Alzheimer's Disease With Organoids

Angelos Papaspyropoulos et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Cell Biology

An in vivo strategy for knockdown of circular RNAs

Nagarjuna Reddy Pamudurti et al.

CELL DISCOVERY (2020)

Article Multidisciplinary Sciences

A large-scale binding and functional map of human RNA-binding proteins

Eric L. Van Nostrand et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

CircRNA inhibits DNA damage repair by interacting with host gene

Xiaolong Xu et al.

MOLECULAR CANCER (2020)

Review Biochemistry & Molecular Biology

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

Rui-Xue Huang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Cell Biology

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Jlenia Guarnerio et al.

CELL RESEARCH (2019)

Review Biochemistry & Molecular Biology

Past, present, and future of circRNAs

Ines Lucia Patop et al.

EMBO JOURNAL (2019)

Article Biochemistry & Molecular Biology

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resection

Nicole Batenburg et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

Long-term expanding human airway organoids for disease modeling

Norman Sachs et al.

EMBO JOURNAL (2019)

Review Biochemistry & Molecular Biology

Circular RNAs in cancer: opportunities and challenges in the field

L. S. Kristensen et al.

ONCOGENE (2018)

Review Biochemistry & Molecular Biology

The Nefarious Nexus of Noncoding RNAs in Cancer

Eleni Anastasiadou et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Biochemistry & Molecular Biology

Circular RNAs function as ceRNAs to regulate and control human cancer progression

Yaxian Zhong et al.

MOLECULAR CANCER (2018)

Article Dermatology

Establishment and characterization of a canine keratinocyte organoid culture system

Dominique J. Wiener et al.

VETERINARY DERMATOLOGY (2018)

Article Multidisciplinary Sciences

Senataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations

Sarah Cohen et al.

NATURE COMMUNICATIONS (2018)

Article Oncology

circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a

Rongfang He et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2017)

Article Biochemistry & Molecular Biology

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

Ivano Legnini et al.

MOLECULAR CELL (2017)

Review Biochemistry & Molecular Biology

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

Andrew N. Blackford et al.

MOLECULAR CELL (2017)

Article Multidisciplinary Sciences

USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response

Yunhui Li et al.

NATURE COMMUNICATIONS (2017)

Article Biotechnology & Applied Microbiology

Circular RNA expression profiles and features in human tissues: a study using RNA-seq data

Tianyi Xu et al.

BMC GENOMICS (2017)

Review Oncology

Circular RNAs and cancer

Jun He et al.

CANCER LETTERS (2017)

Article Cell Biology

Extensive translation of circular RNAs driven by N6-methyladenosine

Yun Yang et al.

CELL RESEARCH (2017)

Article Biochemical Research Methods

JACUSA: site-specific identification of RNA editing events from replicate sequencing data

Michael Piechotta et al.

BMC BIOINFORMATICS (2017)

Review Biochemistry & Molecular Biology

Circular RNAs: Biogenesis, Function and Role in Human Diseases

John Greene et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2017)

Review Genetics & Heredity

RNA mis-splicing in disease

Marina M. Scotti et al.

NATURE REVIEWS GENETICS (2016)

Article Multidisciplinary Sciences

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

Qiupeng Zheng et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs

Tim Schneider et al.

SCIENTIFIC REPORTS (2016)

Article Multidisciplinary Sciences

Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes

Yongchao Dou et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

Agnieszka Rybak-Wolf et al.

MOLECULAR CELL (2015)

Review Biotechnology & Applied Microbiology

Persistent γH2AX: A promising molecular marker of DNA damage and aging

Mohammad Sabbir Siddiqui et al.

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2015)

Article Biochemical Research Methods

Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome

Bastian Linder et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Review Pharmacology & Pharmacy

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where

Ioannis S. Pateras et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Article Biochemistry & Molecular Biology

Regulation of circRNA biogenesis

Ling-Ling Chen et al.

RNA BIOLOGY (2015)

Review Biochemistry & Molecular Biology

RNA-RNA interactions in gene regulation: the coding and noncoding players

Sonia Guil et al.

TRENDS IN BIOCHEMICAL SCIENCES (2015)

Article Multidisciplinary Sciences

Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways

Jae Hoon Bahn et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Exon-intron circular RNAs regulate transcription in the nucleus

Zhaoyong Li et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)

Article Cell Biology

Exon Circularization Requires Canonical Splice Signals

Stefan Starke et al.

CELL REPORTS (2015)

Article Biochemistry & Molecular Biology

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

Atsushi Shibata et al.

MOLECULAR CELL (2014)

Review Biotechnology & Applied Microbiology

Detecting and characterizing circular RNAs

William R. Jeck et al.

NATURE BIOTECHNOLOGY (2014)

Editorial Material Multidisciplinary Sciences

Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

Ashok R. Venkitaraman

SCIENCE (2014)

Article Biotechnology & Applied Microbiology

Expanded identification and characterization of mammalian circular RNAs

Junjie U. Guo et al.

GENOME BIOLOGY (2014)

Review Biochemistry & Molecular Biology

Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes

Geeta J. Narlikar et al.

Article Biochemistry & Molecular Biology

Circular RNAs are abundant, conserved, and associated with ALU repeats

William R. Jeck et al.

Article Oncology

Protumorigenic Activity of Plasminogen Activator Inhibitor-1 Through an Antiapoptotic Function

Hua Fang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2012)

Review Biochemistry & Molecular Biology

R Loops: From Transcription Byproducts to Threats to Genome Stability

Andres Aguilera et al.

MOLECULAR CELL (2012)

Review Biochemistry & Molecular Biology

The DNA Damage Response: Making It Safe to Play with Knives

Alberto Ciccia et al.

MOLECULAR CELL (2010)

Review Cell Biology

Genomic instability - an evolving hallmark of cancer

Simona Negrini et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

TERRA: telomeric repeat-containing RNA

Brian Luke et al.

EMBO JOURNAL (2009)

Article Biotechnology & Applied Microbiology

Effect of 5′UTR introns on gene expression in Arabidopsis thaliana

Betty Y. W. Chung et al.

BMC GENOMICS (2006)

Article Biochemistry & Molecular Biology

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

SY Fang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2000)