期刊
CANCERS
卷 13, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/cancers13194984
关键词
pancreatic cancer; TGF beta; stroma; fibroblasts; CAFs
类别
资金
- Cancer Research UK [A17196, A29996, A23526, A31287]
Pancreatic ductal adenocarcinoma is an aggressive disease with limited available therapies, notable for its high tumour complexity and recent findings on the intricacy of signalling within the stroma, particularly the molecular and functional heterogeneity of cancer associated fibroblasts. While some progress has been made, there are still considerable gaps in our knowledge that require further research efforts.
Pancreatic ductal adenocarcinoma is an aggressive disease for which there are very few available therapies. It is notable for its high degree of tumour complexity, with the tumour microenvironment often accounting for the majority of the tumour volume. Until recently, the biology of the stroma was poorly understood, particularly in terms of heterogeneity. Recent research, however, has shed light on the intricacy of signalling within the stroma and particularly the molecular and functional heterogeneity of the cancer associated fibroblasts. In this review, we summarise the recent improvements in our understanding of the different fibroblast populations within PDAC, with a focus on the role TGF beta plays to dictate their formation and function. These studies have highlighted some of the reasons for the failure of trials targeting the tumour stroma, however, there are still considerable gaps in our knowledge, and more work is needed to make effective fibroblast targeting a reality in the clinic.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据