4.6 Review

Autophagy Regulation on Cancer Stem Cell Maintenance, Metastasis, and Therapy Resistance

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell & Tissue Engineering

Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells' Role in Tumor Progression

Shivani Baisiwala et al.

Summary: Cancer-initiating cells (CICs) play a significant role in cancer progression, tumor invasion, metastasis, and therapeutic resistance, highlighting the importance of understanding and targeting CICs in clinical therapeutics.

STEM CELL REVIEWS AND REPORTS (2022)

Review Gastroenterology & Hepatology

The Tumor Microenvironment in Cholangiocarcinoma Progression

Luca Fabris et al.

HEPATOLOGY (2021)

Article Biochemistry & Molecular Biology

DAPK3 inhibits gastric cancer progression via activation of ULK1-dependent autophagy

Guan-Man Li et al.

Summary: The study demonstrates that tumor-suppressive function of DAPK3 is dependent on autophagy process through direct phosphorylation of ULK1 at Ser556, enhancing ULK1 complex formation and VPS34 complex activation. Clinical samples also show that coordinated expression of DAPK3 with ULK1 Ser556 phosphorylation is associated with favorable survival outcomes in gastric cancer patients. This suggests that DAPK3 may serve as a promising prognostic autophagy-associated marker in gastric cancer.

CELL DEATH AND DIFFERENTIATION (2021)

Article Oncology

ATG7-mediated autophagy involves in miR-138-5p regulated self-renewal and invasion of lung cancer stem-like cells derived from A549 cells

Qian Zhou et al.

Summary: Activation and proliferation of cancer stem cells play crucial roles in malignant tumors, including lung cancer, with miR-138-5p identified as a key regulator in self-renewal and invasion of lung cancer stem-like cells. Autophagy was found to be essential in maintaining self-renewal and invasion ability of lung cancer stem-like cells, with miR-138-5p suppressing ATG7-mediated autophagy to exert anti-tumor effects.

ANTI-CANCER DRUGS (2021)

Review Medicine, Research & Experimental

EMT, cancer stem cells and autophagy; The three main axes of metastasis

Ghader Babaei et al.

Summary: Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major factors contributing to cancer cell metastasis. Autophagy has recently gained attention, playing a dual role in cancer cell development depending on cancer type, tissue, and stage. Studies show different signaling pathways are involved in cancer stem cells, autophagy, and EMT. Investigating effective signaling pathways in all three processes could help determine appropriate therapeutic goals.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Review Oncology

An overview of autophagy: Mechanism, regulation and research progress

Weiya Cao et al.

Summary: Autophagy is a process in cells where autophagosomes are formed to degrade cellular contents for cell homeostasis. It involves complex regulatory mechanisms and multiple signaling pathways. Autophagy and apoptosis share common stimulating factors and regulatory proteins, but differ in their induction thresholds.

BULLETIN DU CANCER (2021)

Article Biology

Down-regulation of autophagy-associated protein increased acquired radio-resistance bladder cancer cells sensitivity to taxol

Xiangli Ma et al.

Summary: Long-term fractionated irradiation is an effective method to establish the ARR-phenotype bladder cancer cell model, by enriching bladder cancer stem cells (BCSCs) and enhancing cells migration and invasion. Inhibiting the expression of autophagy-related proteins and using autophagy inhibitor can increase the sensitivity of ARR cells to taxol, indicating the potential important role of autophagy in chemical tolerance of ARR cells.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

Article Cell Biology

Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53

Jianyu Wang et al.

Summary: This study elucidates a new mechanism underlying the oncogenic activity of autophagy in cancer stem cells, showing that autophagy enhances the stemness of lung CSCs by degrading p53, and that Zeb1 is essential for TP53 regulation of CSC self-renewal. Additionally, Atg5 and Zeb1 are identified as poor prognostic markers of lung cancer through TCGA data mining.

CELL DEATH & DISEASE (2021)

Review Cell Biology

Hedgehog Signaling, a Critical Pathway Governing the Development and Progression of Hepatocellular Carcinoma

Jia Ding et al.

Summary: This review focuses on the role and potential mechanisms of Hh signaling in liver cancer, highlighting its impact on HCC initiation, progression, drug resistance, and metastasis. It emphasizes that exploring the deep mechanisms of Hh signaling can guide individualized HCC management.
Article Cell Biology

SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial-mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancer

Yin Zhu et al.

Summary: The study elucidated the mechanisms by which SOX2 regulates ABCC2 in colorectal cancer, along with beta-catenin, Beclin1, and autophagy signaling, affecting chemoresistance, stemness, and EMT. Clinical analyses revealed a positive correlation between high ABCC2 and Beclin1 expression with SOX2, associated with poor prognosis in CRC patients. Xenograft models confirmed that inhibition of SOX2 expression and autophagy restrained tumor growth and chemoresistance in vivo.

CELL DEATH & DISEASE (2021)

Article Cell Biology

YAP inhibits autophagy and promotes progression of colorectal cancer via upregulating Bcl-2 expression

Lan Jin et al.

Summary: Colorectal cancer is a highly aggressive and lethal cancer, with autophagy playing a complex role in its pathobiology. The transcriptional coactivator YAP has been found to negatively regulate autophagy in CRC cells, promoting tumor progression by upregulating the apoptosis-inhibitory protein Bcl-2 through TEAD interaction, thereby suppressing autophagy-related cell death. Targeting the YAP/Bcl-2 pathway may hold promise as a potential therapeutic strategy against CRC.

CELL DEATH & DISEASE (2021)

Review Pharmacology & Pharmacy

Hedgehog signaling in gastrointestinal carcinogenesis and the gastrointestinal tumor microenvironment

Jinghui Zhang et al.

Summary: The Hedgehog (HH) signaling pathway is crucial in gastrointestinal carcinogenesis and the tumor microenvironment (TME), affecting tumor growth, immune tolerance, inflammation, and drug resistance. Inflammatory factors and cancer-associated fibroblasts play vital roles in these processes, and inhibiting HH signaling can normalize the TME. Aberrant HH signaling activation promotes cancer stem cell proliferation and gastrointestinal tumor drug resistance.

ACTA PHARMACEUTICA SINICA B (2021)

Article Cell Biology

Association of Cancer Stem Cell Radio-Resistance Under Ultra-High Dose Rate FLASH Irradiation With Lysosome-Mediated Autophagy

Gen Yang et al.

Summary: The study revealed that ultra-high dose rate FLASH-RT has killing effects on both cancer stem cells (CSC) and normal cancer cells, with CSC showing higher resistance compared to normal cancer cells. Additionally, CSC exhibited higher levels of lysosome and autophagy under FLASH irradiation, indicating potential mechanisms for their radio-resistance.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cell Biology

Afatinib induces pro-survival autophagy and increases sensitivity to apoptosis in stem-like HNSCC cells

Xianfang Liu et al.

Summary: Afatinib induces autophagy in HNSCC cells through mTORC1 suppression, REDD1-TSC1 signaling activation, and ROS generation. Inhibition of autophagy enhances afatinib-induced apoptosis, indicating the potential of targeting pro-survival autophagy in HNSCC cells. Combination treatment with afatinib and autophagy inhibitors may eradicate HNSCC cells, especially cancer stem cells, in clinical therapy.

CELL DEATH & DISEASE (2021)

Article Multidisciplinary Sciences

Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

Valentin J. A. Barthet et al.

Summary: The study presents a genetically engineered mouse model of HCC driven by loss of autophagy and hemizygosity of PTEN, showing the involvement of ductular reaction in HCC development. Following loss of autophagy, mature hepatocytes dedifferentiate into biliary-like liver progenitor cells, leading to HCC. Deletion of YAP and TAZ transcription factors reverses the dedifferentiation and tumorigenesis, suggesting new potential targets for therapeutic intervention.

SCIENCE ADVANCES (2021)

Review Cell Biology

Cancer Stem Cells: Emerging Key Players in Immune Evasion of Cancers

Martina Mang Leng Lei et al.

Summary: Immune cells play a crucial role in driving cancer cells towards stemness and enabling cancer stem cells to evade immune surveillance by affecting various immune cells in the tumor microenvironment. Targeting CSCs with immunotherapy disrupts the interaction between immune cells and CSCs, offering a novel strategy against cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Oncology

Cancer stem cell-immune cell crosstalk in tumour progression

Defne Bayik et al.

Summary: The development of tumors is affected by cellular heterogeneity and an immunosuppressive tumor microenvironment, which interact with each other and lead to therapeutic resistance. The interaction between cancer stem cells and infiltrating immune cell populations in the tumor microenvironment promotes tumor development and immune evasion.

NATURE REVIEWS CANCER (2021)

Editorial Material Cell Biology

Neuronal autophagy declines substantially with age and is rescued by overexpression of WIPI2

Andrea K. H. Stavoe et al.

AUTOPHAGY (2020)

Article Immunology

The role of JAK/STAT signaling pathway and its inhibitors in diseases

Ping Xin et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Article Oncology

A novel model of liver cancer stem cells developed from induced pluripotent stem cells

Said M. Afify et al.

BRITISH JOURNAL OF CANCER (2020)

Article Biochemistry & Molecular Biology

Jervine inhibits non-small cell lung cancer (NSCLC) progression by suppressing Hedgehog and AKT signaling via triggering autophagy-regulated apoptosis

Wei Lei et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Gastroenterology & Hepatology

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Jesus M. Banales et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Oncology

Evolution of the Experimental Models of Cholangiocarcinoma

Annamaria Massa et al.

CANCERS (2020)

Editorial Material Biochemistry & Molecular Biology

NF-kappa B and Disease

Paola Poma

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Oncology

The interaction mechanism between autophagy and apoptosis in colon cancer

Qingqiang Xie et al.

TRANSLATIONAL ONCOLOGY (2020)

Review Gastroenterology & Hepatology

Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances

Keisaku Sato et al.

HEPATOLOGY (2019)

Review Biochemistry & Molecular Biology

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

Francesca Nazio et al.

CELL DEATH AND DIFFERENTIATION (2019)

Article Cell Biology

LC3-associated phagocytosis at a glance

Bradlee L. Heckmann et al.

JOURNAL OF CELL SCIENCE (2019)

Review Oncology

Cellular Plasticity in Cancer

Salina Yuan et al.

CANCER DISCOVERY (2019)

Article Pharmacology & Pharmacy

Reciprocal Regulation of Chaperone-Mediated Autophagy/Microautophagy and Exosome Release

Mutsumi Oshima et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2019)

Review Developmental Biology

Autophagy in stem cells: repair, remodelling and metabolic reprogramming

Patricia Boya et al.

DEVELOPMENT (2018)

Review Gastroenterology & Hepatology

Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma

Fang Huang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

Article Biochemistry & Molecular Biology

Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells

Kai Liu et al.

MOLECULAR CELL (2017)

Article Cell Biology

Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

Alejandro Vazquez-Martin et al.

AGING-US (2016)

Article Multidisciplinary Sciences

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells

Pingping Zhu et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

NF-kappaB-inducing kinase regulates stem cell phenotype in breast cancer

Karla Vazquez-Santillan et al.

SCIENTIFIC REPORTS (2016)

Review Cell & Tissue Engineering

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

Wanyin Chen et al.

STEM CELLS INTERNATIONAL (2016)

Review Pharmacology & Pharmacy

The modulation of ABC transporter-mediated multidrug resistance in cancer: A review of the past decade

Rishil J. Kathawala et al.

DRUG RESISTANCE UPDATES (2015)

Article Developmental Biology

Role of autophagy in the maintenance and function of cancer stem cells

Ilio Vitale et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Drugging Topoisomerases: Lessons and Challenges

Yves Pommier

ACS CHEMICAL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

The Cystine/Glutamate Antiporter System xc- in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

Jan Lewerenz et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Pharmacology & Pharmacy

Glioblastoma cancer stem cells: Role of the microenvironment and therapeutic targeting

Luca Persano et al.

BIOCHEMICAL PHARMACOLOGY (2013)

Article Cell Biology

The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells

Javier A. Menendez et al.

CELL CYCLE (2013)

Review Oncology

Role of hypoxia-inducible factors in breast cancer metastasis

Daniele M. Gilkes et al.

FUTURE ONCOLOGY (2013)

Review Medicine, Research & Experimental

Cancer stem cells in the development of liver cancer

Taro Yamashita et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Biochemistry & Molecular Biology

mTOR Signaling in Growth Control and Disease

Mathieu Laplante et al.

Article Pharmacology & Pharmacy

Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development

K. Moitra et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)

Review Cell Biology

Mechanisms of mitophagy

Richard J. Youle et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)

Article Cell Biology

Oncogenic Activation of NF-kappa B

Louis M. Staudt

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)

Article Cell Biology

Regulation of autophagy by cytoplasmic p53

Ezgi Tasdemir et al.

NATURE CELL BIOLOGY (2008)

Article Multidisciplinary Sciences

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

Clement A. Gautier et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Genetics & Heredity

MGMT hypermethylation: A prognostic foe, a predictive friend

Filipe V. Jacinto et al.

DNA REPAIR (2007)

Article Oncology

Aberrant activation of Notch signaling in human breast cancer

S Stylianou et al.

CANCER RESEARCH (2006)

Article Biochemistry & Molecular Biology

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

S Pattingre et al.

Article Medicine, General & Internal

MGMT gene silencing and benefit from temozolomide in glioblastoma

ME Hegi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Review Oncology

Microtubules as a target for anticancer drugs

MA Jordan et al.

NATURE REVIEWS CANCER (2004)

Review Cardiac & Cardiovascular Systems

Role of the JAK-STAT pathway in protection against myocardial ischemia/reperfusion injury

R Bolli et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2003)