4.6 Article

A Retrospective Cross-Sectional Cohort Trial Assessing the Prevalence of MTHFR Polymorphisms and the Influence of Diet on Platinum Resistance in Ovarian Cancer Patients

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Review Cell Biology

Epigenetics of Male Infertility: The Role of DNA Methylation

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Summary: Research has shown a correlation between sperm DNA methylation and male infertility, with various genes displaying differential methylation patterns in impaired spermatogenesis and reproductive dysfunction. Specifically, DNA methylation defects in MEST and H19 within imprinted genes, as well as MTHFR within non-imprinted genes, have been linked to male infertility. Further studies are needed to better understand the mechanisms affecting methylation in sperm and its impact on male infertility.

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