4.6 Article

A Novel Prognostic Biomarker Panel for Early-Stage Colon Carcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Current Microsatellite Instability Testing in Management of Colorectal Cancer

Belinda L. Sun

Summary: Colorectal cancer is the third most common cancer worldwide, with approximately 15% of cases showing microsatellite instability-high. MSI-H CRCs have distinct molecular, morphologic, and clinical features, showing poor response to standard chemotherapy but positive response to immunotherapy.

CLINICAL COLORECTAL CANCER (2021)

Article Oncology

The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1

Ming Yi et al.

Summary: The bispecific antibody YM101 can simultaneously target the TGF-beta and PD-L1 pathways, demonstrating superior anti-tumor efficacy. YM101 enhances the anti-tumor immune response by increasing the numbers of tumor infiltrating lymphocytes and dendritic cells, elevating the ratio of M1/M2, and enhancing cytokine production in T cells.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Review Oncology

Functional outcomes of surgery for colon cancer: A systematic review and meta-analysis

Sanne J. Verkuijl et al.

Summary: Functional outcomes following surgery for colon cancer are common, do not improve over time, and are not dependent on the type of colectomy. In addition to fecal incontinence, constipation-associated symptoms are also highly prevalent.
Article Oncology

PD-L1 as a Prognostic Factor in Early-Stage Colon Carcinoma within the Immunohistochemical Molecular Subtype Classification

Pablo Azcue et al.

Summary: Colorectal cancer (CRC) is a heterogeneous disease with ongoing efforts to identify biomarkers for more targeted therapeutic approaches. PD-L1 expression is being investigated as a potential prognostic factor, with promising results in early-stage patients. The CMS classification system, although acknowledged, has yet to be implemented in clinical practice, but integrating PD-L1 expression with CMS may help identify patients with worse prognosis who could benefit from more aggressive treatment.

CANCERS (2021)

Review Biochemistry & Molecular Biology

Molecular subtypes of colorectal cancer: An emerging therapeutic opportunity for personalized medicine

Manish Pratap Singh et al.

Summary: Molecular subtypes-based therapies provide a new potential framework for precise outcomes in clinical settings, as colorectal cancer is a highly heterogeneous malignancy with different pathological and genetic signatures in each subtype. Designing therapeutic stratification based on these features may lead to improved treatment outcomes.

GENES & DISEASES (2021)

Article Oncology

Cancer statistics, 2020

Rebecca L. Siegel et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2020)

Review Oncology

Clinical Development of Immunotherapy for Deficient Mismatch Repair Colorectal Cancer

Jane Thomas et al.

CLINICAL COLORECTAL CANCER (2020)

Article Oncology

Stromal PD-1/PD-L1 Expression Predicts Outcome in Colon Cancer Patients

Jacqueline Wyss et al.

CLINICAL COLORECTAL CANCER (2019)

Article Oncology

Prognostic role of glycolysis for cancer outcome: evidence from 86 studies

Min Yu et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2019)

Article Pathology

CDX2 and Muc2 immunohistochemistry as prognostic markers in stage II colon cancer

Matthew J. Cecchini et al.

HUMAN PATHOLOGY (2019)

Article Gastroenterology & Hepatology

Low expression of MUC2 is associated with longer disease-free survival in patients with colorectal carcinoma

Jaudah Al-Maghrabi et al.

SAUDI JOURNAL OF GASTROENTEROLOGY (2019)

Article Oncology

Mechanisms regulating PD-L1 expression on tumor and immune cells

Shuming Chen et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Gastroenterology & Hepatology

Prognostic Value of MUC2 Expression in Colorectal Cancer: A Systematic Review and Meta-Analysis

Chao Li et al.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2018)

Article Gastroenterology & Hepatology

Differential expression of mucin 1 and mucin 2 in colorectal cancer

Aldona Kasprzak et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2018)

Review Public, Environmental & Occupational Health

Sodium-glucose cotransporters: new targets of cancer therapy?

Ivana Vrhovac Madunic et al.

ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE AND TOXICOLOGY (2018)

Article Oncology

Prognostic impact of CDX2 in stage II colon cancer: results from two nationwide cohorts

Torben Frostrup Hansen et al.

BRITISH JOURNAL OF CANCER (2018)

Review Oncology

E-cadherin: A potential biomarker of colorectal cancer prognosis (Review)

Niki Christou et al.

ONCOLOGY LETTERS (2017)

Article Pathology

CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer

J. Olsen et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2016)

Article Gastroenterology & Hepatology

Differences between colon and rectal cancer in complications, short-term survival and recurrences

Max P. L. van der Sijp et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2016)

Article Medicine, General & Internal

CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer

Piero Dalerba et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Oncology

Rectal and colon cancer: Not just a different anatomic site

K. Tamas et al.

CANCER TREATMENT REVIEWS (2015)

Article Biochemistry & Molecular Biology

The consensus molecular subtypes of colorectal cancer

Justin Guinney et al.

NATURE MEDICINE (2015)

Article Gastroenterology & Hepatology

Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients

Jeong Mo Bae et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2015)

Article Gastroenterology & Hepatology

Immunohistochemical study of MUC1, MUC2 and MUC5AC in colorectal carcinoma and review of literature

Mrunal Kesari et al.

INDIAN JOURNAL OF GASTROENTEROLOGY (2015)

Article Biochemistry & Molecular Biology

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

Felipe De Sousa E Melo et al.

NATURE MEDICINE (2013)

Article Gastroenterology & Hepatology

Differential mucin phenotypes and their significance in a variation of colorectal carcinoma

Yasuo Imai et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

Article Surgery

Clinical Significance of Serum Soluble E-cadherin in Colorectal Carcinoma

Yoshinaga Okugawa et al.

JOURNAL OF SURGICAL RESEARCH (2012)

Article Medicine, General & Internal

GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker

Katia C. Carvalho et al.

CLINICS (2011)

Article Gastroenterology & Hepatology

Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas

Young Jin Jun et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2011)

Article Developmental Biology

Cdx2 regulates patterning of the intestinal epithelium

Stephanie Grainger et al.

DEVELOPMENTAL BIOLOGY (2010)

Article Oncology

Relationship of CDX2 Loss with Molecular Features and Prognosis in Colorectal Cancer

Yoshifumi Baba et al.

CLINICAL CANCER RESEARCH (2009)

Review Pathology

Molecular classification and correlates in colorectal cancer

Shuji Ogino et al.

JOURNAL OF MOLECULAR DIAGNOSTICS (2008)

Article Multidisciplinary Sciences

The consensus coding sequences of human breast and colorectal cancers

Tobias Sjoeblom et al.

SCIENCE (2006)

Article Oncology

Soluble serum E-cadherin as a marker of tumour progression in colorectal cancer patients

C Wilmanns et al.

CLINICAL & EXPERIMENTAL METASTASIS (2004)