4.6 Review

In Vivo and In Vitro Models of Hepatocellular Carcinoma: Current Strategies for Translational Modeling

期刊

CANCERS
卷 13, 期 21, 页码 -

出版社

MDPI
DOI: 10.3390/cancers13215583

关键词

hepatocarcinogenesis; liver cancer; animal model; cell culture; gene mutation; epigenetic alteration; translational research

类别

资金

  1. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [18/10953-9, 16/14420-0, 16/12015-0]
  2. Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [310557/2019-4]
  3. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brasil [001]
  4. Fund for Scientific Research-Flanders [G009514N, G010214N]
  5. University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel) [2018-13]
  6. Center for Alternatives to Animal Testing at Johns Hopkins University-USA [2018-13]
  7. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/10953-9, 16/12015-0] Funding Source: FAPESP

向作者/读者索取更多资源

Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant neoplasia, with few available anti-HCC drugs. The development of HCC models is essential to understanding the disease and improving diagnostic and therapeutic strategies. Various molecular factors contribute to the pathogenesis of HCC, making the establishment of accurate models crucial for translational research.
Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of HCC models has become essential for both basic and translational research, improving the understanding of HCC pathophysiology and molecular landscape. The present paper provides a state-of-the-art overview of in vivo and in vitro models used for translational modeling of HCC, focusing on their molecular hallmarks. Our paper depicts the key features, advantages and disadvantages of the main bioassays available, shedding light on standard HCC model choice. Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the third leading cause of cancer-related death globally. HCC is a complex multistep disease and usually emerges in the setting of chronic liver diseases. The molecular pathogenesis of HCC varies according to the etiology, mainly caused by chronic hepatitis B and C virus infections, chronic alcohol consumption, aflatoxin-contaminated food, and non-alcoholic fatty liver disease associated with metabolic syndrome or diabetes mellitus. The establishment of HCC models has become essential for both basic and translational research to improve our understanding of the pathophysiology and unravel new molecular drivers of this disease. The ideal model should recapitulate key events observed during hepatocarcinogenesis and HCC progression in view of establishing effective diagnostic and therapeutic strategies to be translated into clinical practice. Despite considerable efforts currently devoted to liver cancer research, only a few anti-HCC drugs are available, and patient prognosis and survival are still poor. The present paper provides a state-of-the-art overview of in vivo and in vitro models used for translational modeling of HCC with a specific focus on their key molecular hallmarks.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据