4.6 Review

Upper Gastrointestinal Cancer Surveillance in Lynch Syndrome

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Effectiveness of a surveillance program of upper endoscopy for upper gastrointestinal cancers in Lynch syndrome patients

Amanda H. Ceravolo et al.

Summary: This study describes an EGD surveillance program for upper gastrointestinal precursor lesions and cancer in LS patients. The data suggests that surveillance EGD is a useful tool to help detect precancerous and cancerous upper GI lesions in LS patients. More data are needed to determine the appropriate surveillance interval.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2022)

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Clinically actionable findings on surveillance EGD in asymptomatic patients with Lynch syndrome

Natalie Farha et al.

Summary: Approximately 1 in 6 asymptomatic patients with LS undergoing EGD surveillance were found to have clinically actionable findings. Five patients (1.5%) were diagnosed with early-stage upper gastrointestinal cancers, suggesting the effectiveness of both baseline and follow-up EGD surveillance in detecting early-stage UGI cancers in asymptomatic LS patients.

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The unnatural history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance

Aysel Ahadova et al.

Summary: Despite regular colonoscopy, a significant proportion of individuals with Lynch syndrome still develop colorectal cancer, leading to debates on the reasons behind this surprising observation. Further studies are needed to address this issue and improve CRC prevention strategies for LS individuals.

INTERNATIONAL JOURNAL OF CANCER (2021)

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European guidelines from theEHTGandESCPfor Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

T. T. Seppala et al.

Summary: Lynch syndrome is the most common genetic predisposition for hereditary cancer but remains underdiagnosed. The European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP) developed clinical guidance focusing on surgical and gastroenterological aspects of the cancer spectrum.

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Value of uppergastrointestinalendoscopy for gastric cancer surveillance in patients with Lynch syndrome

Swetlana Ladigan-Badura et al.

Summary: Regular upper GI endoscopy surveillance for LS patients starting from the age of 30 can successfully detect gastric cancer in early stages, leading to more frequent diagnoses in early-stage disease compared to symptomatic diagnoses. The study emphasizes the importance of early detection through regular screenings.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Epidemiology and Outcomes of Young-Onset Esophageal Adenocarcinoma: An Analysis from a Population-Based Database

Don C. Codipilly et al.

Summary: The incidence of young-onset esophageal adenocarcinoma is increasing, with a higher proportion presenting at advanced stages and experiencing poorer outcomes compared to older patients. Current diagnostic and management strategies for this population may need to be reevaluated.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2021)

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Upper Gastrointestinal Lesions during Endoscopy Surveillance in Patients with Lynch Syndrome: A Multicentre Cohort Study

Romain Chautard et al.

Summary: Patients with Lynch syndrome have an increased risk of upper gastrointestinal cancers, particularly after the age of 40. This study found frequent neoplastic lesions in Lynch patients over 40 years old during upper gastrointestinal endoscopy, suggesting the need for screening in this population.

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Early detection of duodenal cancer by upper gastrointestinal-endoscopy in Lynch syndrome

Deepak B. Vangala et al.

Summary: Early detection of duodenal cancer (DC) through esophago-gastro-duodenoscopy (EGD) in Lynch syndrome (LS) patients is feasible, with a higher rate in the surveillance group. Despite factors like family history and genetic mutations, a significant proportion of patients can benefit from early detection through surveillance.

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Using Immunohistochemistry to Expand the Spectrum of Lynch Syndrome-Related Tumors

Natalie Farha et al.

Summary: Chromosomal instability is the most common genetic process leading to sporadic colorectal cancer, while mismatch repair deficiency is the predominant cancer pathway in patients with Lynch syndrome. IHC staining helps expand the spectrum of LS-related tumors.

ACG CASE REPORTS JOURNAL (2021)

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Clinical Factors Associated With Gastric Cancer in Individuals With Lynch Syndrome

Jaihwan Kim et al.

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Refining Risk Factors for Gastric Cancer in Patients With Lynch Syndrome to Optimize Surveillance Esophagogastroduodenoscopy

Gautam Mankaney et al.

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Pedunculated Upper Esophageal Adenocarcinoma in Lynch Syndrome

Hajime Sasaki et al.

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Sheila E. Crowe

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Gastric cancer in Lynch syndrome is associated with underlying immune gastritis

Tomer Adar et al.

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Early Esophageal Cancer: A Gastroenterologist's Disease

Joseph Spataro et al.

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ASGE guideline on screening and surveillance of Barrett's esophagus

Bashar Qumseya et al.

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Current recommendations for surveillance, risk reduction and therapy in Lynch syndrome patients

Robert Hueneburg et al.

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Cancer statistics, 2019

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Duodenal tumor risk in Lynch syndrome

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How to Perform a High-Quality Examination in Patients With Barrett's Esophagus

Martin A. Everson et al.

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Low yield of gastroscopy in patients with Lynch syndrome

Polymnia Galiatsatos et al.

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Adverse Event and Complication Management in Gastrointestinal Endoscopy

James M. Richter et al.

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Idan Levy et al.

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Equivalent Helicobacter pylori infection rates in Lynch syndrome mutation carriers with and without a first-degree relative with gastric cancer

Eline C. Soer et al.

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Santosh Shenoy

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ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

Sapna Syngal et al.

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Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy

Jasmijn F. Haanstra et al.

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Milestones of Lynch syndrome: 1895-2015

Henry T. Lynch et al.

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Causes and consequences of microsatellite instability in gastric carcinogenesis

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Familial risk-colorectal cancer: ESMO Clinical Practice Guidelines

J. Balmana et al.

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Dysphagia in Lynch Syndrome

Seth Sweetser et al.

GASTROENTEROLOGY (2013)

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Clinical significance of heterotopic gastric mucosal patch of the proximal esophagus

Vui Heng Chong

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Cancer Risks Associated With Germline Mutations in MLH1, MSH2, and MSH6 Genes in Lynch Syndrome

Valerie Bonadona et al.

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The prevalence of Barrett's esophagus in the US: estimates from a simulation model confirmed by SEER data

T. J. Hayeck et al.

DISEASES OF THE ESOPHAGUS (2010)

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Risk and Epidemiological Time Trends of Gastric Cancer in Lynch Syndrome Carriers in The Netherlands

Lisette G. Capelle et al.

GASTROENTEROLOGY (2010)

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Prevalence of Barrett's esophagus in the general population:: An endoscopic study

J Ronkainen et al.

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The role of mismatch repair gene defects in the development of adenomas in patients with HNPCC

AE De Jong et al.

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No support for endoscopic surveillance for gastric cancer in hereditary non-polyposis colorectal cancer

L Renkonen-Sinisalo et al.

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