Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone

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A requirement for p120-catenin in the metastasis of invasive ductal breast cancer

Sarah J. Kurley et al.

Summary: The study shows that p120 plays a positive role in the tumor microenvironment and metastatic colonization of distant sites, while its downregulation in primary tumors indirectly enhances metastatic dissemination.

JOURNAL OF CELL SCIENCE (2021)

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Article Oncology

Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation

Yansen Xiao et al.

Summary: The study reveals that tumor-secreted protease CTSC promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.

CANCER CELL (2021)

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Article Chemistry, Multidisciplinary

RNF219/α-Catenin/LGALS3 Axis Promotes Hepatocellular Carcinoma Bone Metastasis and Associated Skeletal Complications

Shuxia Zhang et al.

Summary: The study reveals that HCC-secreted LGALS3 plays a crucial role in bone metastasis of HCC patients by promoting the formation of pre-metastatic niche and inducing skeletal-related events. Treatment with vertiporfin, a drug for macular degeneration, effectively inhibits skeletal complications of HCC.

ADVANCED SCIENCE (2021)

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Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Review Oncology

Novel approaches to target the microenvironment of bone metastasis

Lorenz C. Hofbauer et al.

Summary: Bone metastases are a common and severe complication of advanced-stage cancers, particularly in patients with breast and prostate cancer. The interactions between cells in the bone microenvironment affect tumor cell migration, dormancy, and resistance to treatment, and interrupting these interactions can help prevent or treat skeletal metastases.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Review Oncology

Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets

Yiran Liang et al.

SEMINARS IN CANCER BIOLOGY (2020)

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Review Oncology

Liquid Biopsy-Based Biomarkers of Treatment Response and Resistance

Elaine Kilgour et al.

CANCER CELL (2020)

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Article Biochemistry & Molecular Biology

Elevated serum interleukin-8 is associated with enhanced intratumor neutrophils and reduced clinical benefit of immune-checkpoint inhibitors

Kurt A. Schalper et al.

NATURE MEDICINE (2020)

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Article Developmental Biology

Neural defects caused by total and Wnt1-Cre mediated ablation of p120ctn in mice

Tim Pieters et al.

BMC DEVELOPMENTAL BIOLOGY (2020)

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Article Multidisciplinary Sciences

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

Linbin Yang et al.

NATURE (2020)

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Cell-cell adhesion and 3D matrix confinement determine jamming transitions in breast cancer invasion

Olga Ilina et al.

NATURE CELL BIOLOGY (2020)

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Review Gastroenterology & Hepatology

Adhesion molecules and pancreatitis

Takeshi Sato et al.

JOURNAL OF GASTROENTEROLOGY (2019)

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Review Oncology

Immunotherapy and targeted therapy combinations in metastatic breast cancer

Francisco J. Esteva et al.

LANCET ONCOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Impact of CXCR4 and CXCR7 knockout by CRISPR/Cas9 on the function of triple-negative breast cancer cells

Meng Yang et al.

ONCOTARGETS AND THERAPY (2019)

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Article Oncology

P120 Catenin Isoforms Differentially Associate with Breast Cancer Invasion and Metastasis

Jan-Hendrik Venhuizen et al.

CANCERS (2019)

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Article Biotechnology & Applied Microbiology

P120-Catenin And Its Phosphorylation On Tyr228 Inhibits Proliferation And Invasion In Colon Adenocarcinoma Cells

Xiuming Ding et al.

ONCOTARGETS AND THERAPY (2019)

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Article Oncology

Bone Metastasis of Breast Cancer

Rie K. Tahara et al.

BREAST CANCER METASTASIS AND DRUG RESISTANCE: CHALLENGES AND PROGRESS, 2ND EDITION (2019)

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Review Pathology

The breast tumor microenvironment: role in cancer development, progression and response to therapy

Suruchi Mittal et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2018)

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Review Biochemistry & Molecular Biology

Breast cancer bone metastases: pathogenesis and therapeutic targets

Naomi Brook et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2018)

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Metastatic and triple-negative breast cancer: challenges and treatment options

Sumayah Al-Mahmood et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2018)

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Article Oncology

A central role for cadherin signaling in cancer

Antonis Kourtidis et al.

EXPERIMENTAL CELL RESEARCH (2017)

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Review Genetics & Heredity

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Guangwen Ren et al.

JOURNAL OF MOLECULAR MEDICINE-JMM (2015)

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Article Cell Biology

p120-catenin in cancer - mechanisms, models and opportunities for intervention

Ron C. J. Schackmann et al.

JOURNAL OF CELL SCIENCE (2013)

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Review Oncology

Triple-negative breast cancer: disease entity or title of convenience?

Lisa Carey et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

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Article Multidisciplinary Sciences

Targeted p120-Catenin Ablation Disrupts Dental Enamel Development

John D. Bartlett et al.

PLOS ONE (2010)

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Article Oncology

Site-specific relapse pattern of the triple negative tumors in Chinese breast cancer patients

Yanping Lin et al.

BMC CANCER (2009)

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Article Pathology

p120 catenin reduction and cytoplasmic relocalization leads to dysregulation of E-cadherin in solid pseudopapillary tumors of the pancreas

Runjan Chetty et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2008)

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Article Urology & Nephrology

Prognostic significance of altered p120ctn expression in bladder cancer

Brasil Silva Neto et al.

BJU INTERNATIONAL (2008)

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Article Hematology

Growth factors G-CSF and GM-CSF differentially preserve chemotaxis of neutrophils aging in vitro

Baruch Wolach et al.

EXPERIMENTAL HEMATOLOGY (2007)

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Review Biochemistry & Molecular Biology

p120-catenin: Past and present

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

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Article Multidisciplinary Sciences

Involvement of chemokine receptors in breast cancer metastasis

A Müller et al.

NATURE (2001)

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Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone

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