期刊
CANCERS
卷 14, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/cancers14030705
关键词
rectal cancer; hyperthermia; chemoradiotherapy; tumour control
类别
The addition of regional hyperthermia to standard preoperative chemoradiotherapy improves the complete response rate and long-term recurrence-free survival in locally advanced and recurrent rectal cancer. Hyperthermia plays an important role in increasing tumor regression and reducing the risk of recurrence.
Simple Summary Regional hyperthermia added to standard preoperative chemoradiotherapy for locally advanced and recurrent rectal cancer gives a high complete response rate and an improved long-term recurrence free survival. Hyperthermia was added to standard preoperative chemoradiation for rectal adenocarcinomas in a phase II study. Patients with T3-4 N0-2 M0 rectal cancer or local recurrences were included. Radiation dose was 54 Gy combined with capecitabine 825 mg/m(2) x 2 daily and once weekly oxaliplatin 55 mg/m(2). Regional hyperthermia aimed at 41.5-42.5 degrees C for 60 min combined with oxaliplatin infusion. Radical surgery with total or extended TME technique, was scheduled at 6-8 weeks after radiation. From April 2003 to April 2008, a total of 49 eligible patients were recruited. Median number of hyperthermia sessions were 5.4. A total of 47 out of 49 patients (96%) had the scheduled surgery, which was clinically radical in 44 patients. Complete tumour regression occurred in 29.8% of the patients who also exhibited statistically significantly better RFS and CSS. Rate of local recurrence alone at 10 years was 9.1%, distant metastases alone occurred in 25.6%, including local recurrences 40.4%. RFS for all patients was 54.8% after 5 years and CSS was 73.5%. Patients with T50 temperatures in tumours above median 39.9 degrees C had better RFS, 66.7% vs. 31.3%, p = 0.047, indicating a role of hyperthermia. Toxicity was acceptable.
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