Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β (vol 13, 3105, 2021)

Summary: The study evaluated the therapeutic efficacy of Niclosamide on pancreatic cancer and found that it induced cell death through mitochondrial stress and mTORC1-dependent autophagy. Niclosamide inhibited the Hedgehog (Hh) signaling pathway and promoted cell death through regulation of p-Gsk3 beta.