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Therapeutic Potential of Innate Lymphoid Cells for Multiple Myeloma Therapy

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Summary: This study found that the expression of biomarkers on NK cells may be associated with the prognosis and disease progression of multiple myeloma patients, suggesting these biomarkers could serve as therapeutic targets. The results indicate that NK cells in RR and pSCT patients are less mature, with lower levels of activating receptors DNAM-1, NKG2D, and CD16, and more pronounced differences in the bone marrow, including upregulation of therapeutic targets TIM3, TIGIT, ICOS, and GITR.

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