4.6 Review

Enhancing T Cell Chemotaxis and Infiltration in Glioblastoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

Designing Clinical Trials for Combination Immunotherapy: A Framework for Glioblastoma

Kirit Singh et al.

Summary: Immunotherapy has not shown significant improvement in outcomes for glioblastoma patients due to the multiple and unique mechanisms of immune evasion and escape in this highly heterogeneous tumor. Combinatorial approaches of immune-oriented therapy are required to overcome these mechanisms. The design of clinical trials evaluating these approaches needs careful consideration.

CLINICAL CANCER RESEARCH (2022)

Article Multidisciplinary Sciences

Pericytes regulate vascular immune homeostasis in the CNS

Orsolya Toeroek et al.

Summary: Pericytes regulate leukocyte infiltration in the adult central nervous system and play a role in neuroinflammation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Cell Biology

Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood-brain barrier

Mariana Castro Dias et al.

Summary: The study suggests that tricellular junctions of the BBB serve as novel sites for T cell diapedesis, different from the previously believed cellular junctions. By manipulating the expression of tricellular junctional proteins or targeting chemokines, the ability of T cells to cross the BBB can be enhanced or suppressed.

JOURNAL OF CELL SCIENCE (2021)

Article Cell Biology

Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling

Xiao-Ning Zhang et al.

Summary: The study reveals the role of pericytes in potentiating DDR signaling in GBM cells, and suggests that targeting CCL5-CCR5 signaling could be an effective therapeutic strategy to improve chemotherapeutic efficacy against GBM.

CELL RESEARCH (2021)

Article Gastroenterology & Hepatology

CCL19 enhances CD8+ T-cell responses and accelerates HBV clearance

Yan Yan et al.

Summary: CCL19 enhances Ag-responsive IFN-γ(+) CD8(+) T cells in patients with HBV infection and promotes rapid clearance of intrahepatic HBV in mice.

JOURNAL OF GASTROENTEROLOGY (2021)

Article Cell Biology

Integrin cross-talk modulates stiffness-independent motility of CD4+T lymphocytes

Sarah Hyun Ji Kim et al.

Summary: Recent studies suggest that CD4+ T lymphocytes can migrate on surfaces with different substrate stiffness, with migration speed on ICAM-1 being independent of substrate stiffness. Furthermore, the interaction between VLA-4 and LFA-1 can compensate for deformable substrates.

MOLECULAR BIOLOGY OF THE CELL (2021)

Article Multidisciplinary Sciences

Cellular model system to dissect the isoform-selectivity of Akt inhibitors

Lena Quambusch et al.

Summary: The study focuses on elucidating the specific effects of protein kinase Akt isoforms by establishing an Akt isoform-dependent cellular model system and developing isoform-selective covalent-allosteric Akt inhibitors through X-ray crystallography and structure-based ligand design. This approach allows for the study of isoform-selective effects of Akt inhibition in cancer cells, potentially paving the way for the development of next-generation therapeutics with superior on-target properties.

NATURE COMMUNICATIONS (2021)

Article Medicine, Research & Experimental

Active surveillance characterizes human intratumoral T cell exhaustion

Ran You et al.

Summary: Intratumoral T cells in an exhausted state exhibit variable mobility within human tumors, with speed inversely correlated with local tumor density and differing by region and patient. This study reveals dynamic states of T cells in individual human tumors and suggests an active program in exhausted T cells beyond mere incapacitation.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Article Cell Biology

Meningeal lymphatic vessels regulate brain tumor drainage and immunity

Xueting Hu et al.

CELL RESEARCH (2020)

Article Multidisciplinary Sciences

VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours

Eric Song et al.

NATURE (2020)

Review Oncology

PD-1 Inhibitors: Do they have a Future in the Treatment of Glioblastoma?

Mustafa Khasraw et al.

CLINICAL CANCER RESEARCH (2020)

Article Oncology

EGFR/Ras-induced CCL20 production modulates the tumour microenvironment

Andreas Hippe et al.

BRITISH JOURNAL OF CANCER (2020)

Article Immunology

Nivolumab-induced seronegative encephalitis

Goncalo Cabral et al.

JOURNAL OF NEUROIMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy

Soniya Bastola et al.

NATURE COMMUNICATIONS (2020)

Review Immunology

Metabolic coordination of T cell quiescence and activation

Nicole M. Chapman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury

Mary T. Joy et al.

Review Oncology

Brain Tumor Microenvironment and Host State: Implications for Immunotherapy

William Tomaszewski et al.

CLINICAL CANCER RESEARCH (2019)

Review Immunology

CAR T cells for brain tumors: Lessons learned and road ahead

David Akhavan et al.

IMMUNOLOGICAL REVIEWS (2019)

Article Neurosciences

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss

Angeliki M. Nikolakopoulou et al.

NATURE NEUROSCIENCE (2019)

Article Biochemical Research Methods

Engineering of human brain organoids with a functional vascular-like system

Bilal Cakir et al.

NATURE METHODS (2019)

Article Endocrinology & Metabolism

Clinical heterogeneity of hypophysitis secondary to PD-1/PD-L1 blockade: insights from four cases

Isabella Lupi et al.

ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS (2019)

Review Neurosciences

Claudin-5: gatekeeper of neurological function

Chris Greene et al.

FLUIDS AND BARRIERS OF THE CNS (2019)

Review Oncology

Chimeric antigen receptor T-cell therapy - assessment and management of toxicities

Sattva S. Neelapu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Clinical Neurology

Neurological Adverse Events Associated with Immune Checkpoint Inhibitors: Diagnosis and Management

Christophoros Astaras et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2018)

Review Cell Biology

Metabolic regulation of leukocyte motility and migration

Federica M. Marelli-Berg et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2018)

Article Neurosciences

Generation of human vascularized brain organoids

Missy T. Pham et al.

NEUROREPORT (2018)

Article Multidisciplinary Sciences

A molecular atlas of cell types and zonation in the brain vasculature

Michael Vanlandewijck et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

Sequestration of T cells in bone marrow in the setting of glioblastoma and other intracranial tumors

Pakawat Chongsathidkiet et al.

NATURE MEDICINE (2018)

Article Immunology

Emerging Cellular Therapies for Cancer

Sonia Guedan et al.

Annual Review of Immunology (2018)

Review Clinical Neurology

Neurological complications of immune checkpoint inhibitors: what happens when you take the brakes off' the immune system

Marinos C. Dalakas

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2018)

Review Neurosciences

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

Annika Sommer et al.

MOLECULAR NEURODEGENERATION (2017)

Article Neurosciences

High-dimensional, single-cell characterization of the brain's immune compartment

Ben Korin et al.

NATURE NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Akt signaling is critical for memory CD8+ T-cell development and tumor immune surveillance

Anne Rogel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Cell Biology

Metabolic Reprogramming in Glioma

Marie Strickland et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)

Article Oncology

The Microenvironmental Landscape of Brain Tumors

Daniela F. Quail et al.

CANCER CELL (2017)

Review Immunology

T cell responses in the central nervous system

Thomas Korn et al.

NATURE REVIEWS IMMUNOLOGY (2017)

Review Immunology

The movers and shapers in immune privilege of the CNS

Britta Engelhardt et al.

NATURE IMMUNOLOGY (2017)

Review Clinical Neurology

Vascular, glial, and lymphatic immune gateways of the central nervous system

Britta Engelhardt et al.

ACTA NEUROPATHOLOGICA (2016)

Article Oncology

The role of AKT isoforms in glioblastoma: AKT3 delays tumor progression

Anna Joy et al.

JOURNAL OF NEURO-ONCOLOGY (2016)

Article Multidisciplinary Sciences

Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid

Christian Schlaeger et al.

NATURE (2016)

Article Medicine, General & Internal

Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

Christine E. Brown et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Serum stimulation of CCR7 chemotaxis due to coagulation factor XIIa-dependent production of high-molecular-weight kininogen domain 5

Manish P. Ponda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

Lenka V. Hurton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Immunology

Understanding the Role of T Cells in CNS Homeostasis

Erik Ellwardt et al.

TRENDS IN IMMUNOLOGY (2016)

Article Immunology

Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin

Guillaume Martin-Blondel et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Christina Twyman-Saint Victor et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes

Ignazio Caruana et al.

NATURE MEDICINE (2015)

Article Cell Biology

The Blood-Brain Barrier

Richard Daneman et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)

Article Multidisciplinary Sciences

The Evidence of Glioblastoma Heterogeneity

Akio Soeda et al.

SCIENTIFIC REPORTS (2015)

Letter Clinical Neurology

Severe relapse in a multiple sclerosis patient associated with ipilimumab treatment of melanoma

Edward J. Gettings et al.

MULTIPLE SCLEROSIS JOURNAL (2015)

Article Endocrinology & Metabolism

Immune Checkpoint Inhibitor Therapy Associated Hypophysitis

Moeber Mahzari et al.

CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES (2015)

Article Clinical Neurology

JAML mediates monocyte and CD8 T cell migration across the brain endothelium

Jorge Ivan Alvarez et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2015)

Review Immunology

Enhancement of T cell recruitment and infiltration into tumours

C. Oelkrug et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2014)

Review Clinical Neurology

Ipilimumab treatment associated pituitary hypophysitis: Clinical presentation and imaging diagnosis

Yosef Chodakiewitz et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2014)

Review Immunology

Leukocyte Migration into Inflamed Tissues

Sussan Nourshargh et al.

IMMUNITY (2014)

Article Immunology

Maraviroc Reduces the Regulatory T-Cell Frequency in Antiretroviral-Naive HIV-Infected Subjects

Maria Mar Pozo-Balado et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

Review Immunology

T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases

Hugo Gonzalez et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Article Biochemistry & Molecular Biology

Cytotoxic-T-Lymphocyte Antigen 4 Receptor Signaling for Lymphocyte Adhesion Is Mediated by C3G and Rap1

Yoel Kloog et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Mfsd2a is critical for the formation and function of the blood-brain barrier

Ayal Ben-Zvi et al.

NATURE (2014)

Review Immunology

CNS-specific T cells shape brain function via the choroid plexus

Kuti Baruch et al.

BRAIN BEHAVIOR AND IMMUNITY (2013)

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

Article Pathology

Getting Leukocytes to the Site of Inflammation

W. A. Muller

VETERINARY PATHOLOGY (2013)

Article Pharmacology & Pharmacy

T cell trafficking and metabolism: novel mechanisms and targets for immunomodulation

C. Mauro et al.

CURRENT OPINION IN PHARMACOLOGY (2012)

Article Biochemistry & Molecular Biology

Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity

Petr Busek et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

T cells become licensed in the lung to enter the central nervous system

Francesca Odoardi et al.

NATURE (2012)

Review Immunology

Capture, crawl, cross: the T cell code to breach the blood-brain barriers

Britta Engelhardt et al.

TRENDS IN IMMUNOLOGY (2012)

Review Immunology

Chemokines and the signaling modules regulating integrin affinity

Alessio Montresor et al.

FRONTIERS IN IMMUNOLOGY (2012)

Article Immunology

The profile of Th17 subset in glioma

Jinhui Hu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2011)

Article Immunology

Metabolism, migration and memory in cytotoxic T cells

David Finlay et al.

NATURE REVIEWS IMMUNOLOGY (2011)

Article Multidisciplinary Sciences

Pericytes regulate the blood-brain barrier

Annika Armulik et al.

NATURE (2010)

Article Multidisciplinary Sciences

Pericytes are required for blood-brain barrier integrity during embryogenesis

Richard Daneman et al.

NATURE (2010)

Review Cell Biology

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium

Sussan Nourshargh et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Oncology

Fibroblast growth factor signalling: from development to cancer

Nicholas Turner et al.

NATURE REVIEWS CANCER (2010)

Article Biochemistry & Molecular Biology

Caveolae-mediated Internalization of Occludin and Claudin-5 during CCL2-induced Tight Junction Remodeling in Brain Endothelial Cells

Svetlana M. Stamatovic et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Medicine, General & Internal

A Surgical Safety Checklist to Reduce Morbidity and Mortality in a Global Population.

Alex B. Haynes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Immunology

The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction

Britta Engelhardt et al.

SEMINARS IN IMMUNOPATHOLOGY (2009)

Review Clinical Neurology

Perivascular Spaces and the Two Steps to Neuroinflammation

Trevor Owens et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)

Article Immunology

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

Martin A. Schneider et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Review Immunology

Getting to the site of inflammation: the leukocyte adhesion cascade updated

Klaus Ley et al.

NATURE REVIEWS IMMUNOLOGY (2007)

Article Immunology

Transcriptional regulator Id2 mediates CD8+ T cell immunity

Michael A. Cannarile et al.

NATURE IMMUNOLOGY (2006)

Article Biochemistry & Molecular Biology

Protein kinase Cα-RhoA cross-talk in CCL2-induced alterations in brain endothelial permeability

SM Stamatovic et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Cell Biology

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

J Ikenouchi et al.

JOURNAL OF CELL BIOLOGY (2005)

Article Immunology

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

AM Intlekofer et al.

NATURE IMMUNOLOGY (2005)

Article Biochemistry & Molecular Biology

Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis

M Greter et al.

NATURE MEDICINE (2005)

Article Multidisciplinary Sciences

T cell deficiency leads to cognitive dysfunction: Implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

J Kipnis et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Cell Biology

Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice

T Nitta et al.

JOURNAL OF CELL BIOLOGY (2003)

Review Endocrinology & Metabolism

Anti-inflammatory cytokines: Expression and action in the brain

L Vitkovic et al.

NEUROIMMUNOMODULATION (2001)

Article Pharmacology & Pharmacy

Marimastat: the clinical development of a matrix metalloproteinase inhibitor

AL Thomas et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2000)

Article Cell Biology

Complex phenotype of mice lacking occludin, a component of tight junction strands

M Saitou et al.

MOLECULAR BIOLOGY OF THE CELL (2000)